深部脑刺激手术中双模态脑功能区定位方法研究

项目名称： 深部脑刺激手术中双模态脑功能区定位方法研究

项目编号： No.81471745

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 医药、卫生

项目作者： 王守岩

作者单位： 中国科学院苏州生物医学工程技术研究所

项目金额： 70万元

中文摘要： 深部脑刺激是许多重症神经、精神系统疾病的唯一有效治疗手段，我国有近百万的帕金森、癫痫、抑郁等患者需要接受该手术，而刺激电极植入的准确性是决定手术成功与否的关键因素。本项目面向临床上电极植入功能区靶点精确定位难点，针对三维空间定位、高分辨率、定量客观、功能与结构信息融合的需求，利用微纳加工技术研制多触点三维电极，实现功能相关脑深部场电位特征、结构相关各向异性阻抗谱信息同步获取，结合个体核磁共振影像、几何特征、物理特性进行神经核团三维建模，形成功能、结构双模态信息相融合的术中实时功能靶点探测、确认和评估技术，建立深部脑刺激电极植入分级定位理论和基于神经核团功能区建模分析的个体化神经调控参数客观评估方法。本项目建立的精确定位和调控优化技术将提高深部脑刺激临床治疗效果、减少副作用和节省电池使用寿命，并推动我国深部脑刺激神经调控技术完善和创新。

中文关键词： 局部场电位；阻抗谱；事件相关电位；丘脑底核；帕金森病

英文摘要： Deep brain stimulation is the only effective approach for many neural and psychiatric diseases. There are more than a million people with Parkinson's disease, epilepsy and depression, etc, awaiting for such clinical treatment. The accurate implantation of the deep brain stimulation electrodes is the key to the success of the surgery. To overcome the challenges of accurately targetting the functional area for electrode implantation, this project aims to solve the problems in three dimensional localisation, higher spatial resolution, quantitative and objective measurement, and combination of functional and structural information. Nanotechnology is utilised to produce probing electrodes with multiple contacts distributed over the 3-D surface so that the deep brain local field potentials related to the function of the nucleus and the isometric impedance spectra related to the anatomy are aquired simultaneously. Modelling of the structural and physical properties of the nucleus is built based on MRI imaging of individuals. Intra-operative targetting approach with probing, confirmation and evaluation will be developed according to fusion of functional,structural and anatomical information. The guidance of localisation of deep brain stimulation target will be formed based on multiple stage procedure and the objective evaluation approach of stimulation parameters will be developed based on function of nucleus modelling and analysis. The technology of accurate target localisation and objective optimisation of neuromodulation will improve the effecacy of clinical treatment, reduce side effects and extend the battery life, but also enhance the innovation of key technologies in neuromodulation research field of China.

英文关键词： local field potentials;impedance;event related potential;subthalamus;Parkinson's disease