冻结步态帕金森病患者脑网络多模态磁共振脑功能成像研究

项目名称： 冻结步态帕金森病患者脑网络多模态磁共振脑功能成像研究

项目编号： No.81471654

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 医药、卫生

项目作者： 黄飚

作者单位： 广东省人民医院

项目金额： 70万元

中文摘要： 冻结步态是帕金森病（PD）患者最严重的症状之一，与PD的主要特征性运动相关障碍（震颤、运动迟缓或僵直）无任何关系。冻结步态虽然表现为运动障碍，但实际上是认知障碍。研究冻结步态，可以使我们深入了解PD相关的中枢系统的网络的病理变化。我们前期研究发现，PD患者长期服用多巴胺类药物会损伤认知回路。本课题以冻结步态PD患者为主要研究对象，用弥散张量成像和静息态fMRI等方法，首次探索多巴胺类药物与冻结步态形成的相关性，分析桥脑脚核、额叶在冻结步态中所起的作用，显示冻结步态PD患者桥脑脚核相关神经网络的变化；构建冻结步态PD患者桥脑脚核网络的小世界拓扑结构模型；用多模态磁共振脑功能成像技术揭示冻结步态形成的神经病理机制，为PD患者冻结步态的预防、及时诊断及治疗提供理论指导依据，减少冻结步态的发生。

中文关键词： 帕金森病；冻结步态；功能磁共振成像；脑网络；功能连接

英文摘要： Freezing of gait is one of the most debilitating features of Parkinson's disease (PD), which is not associated with the cardinal features of Parkinson's disease (tremor, bradykinesia or rigidity). Although freezing of gait looks like movement disorder, it is correlated with cognitive dysfunction. Freezing of gait thus offers the opportunity to study various parts of the nervous system that are involved in gait and come to a conceptual framework of the cerebral control of gait. In our previous study, we have found that long time dopaminic therapy could damege the cognitive circuit in PD patients. In the fellowing study,PD patients with freezing of gait will be encased; The diffusion tensor imaging and resting-state functional magnetic resonance imaging （fMRI） will be employed. It is the first study to explore the relation between the dopaminic regime and the freezing of gait. The role of pedunculopontine nucleus and frontal lobe in freezing of gait will be analyzed; The structural network correlated to freezing of gait will be detected；The model of small world topological structure of pedunculopontine network connectivity in PD patients with freezing of gait will be built; The neuropathologic mechanism of PD patients with freezing of gait will be disclosed by using multi-modal fMRI techniques. This study can provide the scientific theory for prevention, diagnose and treatment of PD, and can decrease the possibility of freezing of gait current in PD patients.

英文关键词： Parkinson's disease;freezing of gait;functional magnetic resoance imaging;cerebral network;functional connection