脑老化异质性的认知神经机制：基于静息功能磁共振成像的研究

项目名称： 脑老化异质性的认知神经机制：基于静息功能磁共振成像的研究

项目编号： No.31200847

项目类型： 青年科学基金项目

立项/批准年度： 2013

项目学科： 认知的脑结构与神经基础

项目作者： 李锐

作者单位： 中国科学院心理研究所

项目金额： 24万元

中文摘要： 本项目基于静息功能磁共振成像技术，以成功老化、常态老化和轻度认知损伤为研究对象，研究脑老化异质性的认知神经机制。通过对静息条件下大脑局部活动时频特征、功能连接网络以及全脑连接网络三个层面的探索式分析，识别标志脑老化异质性的关键脑区、关键网络、关键节点和连接路径等影像学标记，在静息脑活动水平系统揭示脑老化异质性的神经基础；同时，建立可运用这些来自不同层面的影像学标记物量化脑功能老化水平的方法。本项目将通过开展老化异质性的脑机制研究促进对脑老化过程特别是脑老化效应和认知老化效应之间联系的理解，同时也为脑功能老化程度的评估以及认知或行为干预后脑功能改善效果的评价等提供科学依据。

中文关键词： 认知老化；异质性；脑机制；功能磁共振成像；可塑性

英文摘要： This study used resting-state functional magnetic resonance imaging (fMRI) technique to investigate the cognitive neural mechanism of heterogeneity in aging. By examining and comparing the dynamic features of resting-state activity including regional time-frequency characteristics, functional connectivity networks, and whole brain connectivity network in successful aging (SA), usual aging (UA) and mild cognitive impairment (MCI), we intend to identify the key brain regions, functional networks, nodes and connective paths that are associated with the heterogeneity of aging, and thus to reveal the neural basis of heterogeneity in cognitive aging in the resting-state brain activity level. In addition, we are interested in establishing the methods that could quantify the levels of brain aging using these imaging markers. The study of the neural mechanism of heterogeneity in aging will promote the further understanding of the process of aging, especially the understanding of the relations between brain aging effects and cognitive aging effects, and also provide scientific basis for the objective assessment of brain aging levels and even the objective evaluations of brain function improvement after cognitive or behavioral interventions for the older people.

英文关键词： cognitive aging；heterogeneity；brain mechanism；fMRI；brain plasticity