项目名称: 金属-有机笼状结构的合成与生物小分子识别
项目编号: No.20801008
项目类型: 青年科学基金项目
立项/批准年度: 2009
项目学科: 生物科学
项目作者: 何成
作者单位: 大连理工大学
项目金额: 20万元
中文摘要: 本项目利用用富含酰胺基团的多齿共轭配体与配位构型匹配的金属离子组装,构筑结构稳定、性能良好的金属-有机笼状或环状化合物,在理解生命体系的有序化组织过程的基础上,开展仿生配位超分子体系研究,开发高选择性的生物小分子探针以及探索高效清洁催化过程。针对生物小分子识别以及催化过程中共同面临的如何提高立体专一性的科学问题,发挥配位键具有明确的方向性和花样繁多的价键结构等优势,以及丰富的物理化学性质,构建金属-有机环(笼)状和孔洞结构,通过弱作用识别位点在空间和能量上的加和与协同,实现对糖类、核苷(酸)、小肽以及NO等生命过程中重要小分子的高选择性识别和荧光响应;并通过金属离子中心和有机构筑基元分别引入催化活性位点,识别特定的底物分子同在环(笼)状和孔洞结构所提供的限制性空间里实现高立体选择性的催化功能。三年间在J Am Chem Soc 、Chem Commun等共发表标注基金号论文11篇,(影响因子大于3的10篇)。
中文关键词: 金属-有机笼状结构;生物小分子识别;立体选择;荧光;催化
英文摘要: The design of artifical chemsensor for the recognition of small biological molecule, is the core topic of supromolecular chemistry and chemobiology.This work plan to build stable metal-organic cages or macrocyles with fantastic functions through the assembly of polydentate ligand rich of amide groups and metal ions with suitable coordination configuration. Such cages or macrocycles would slectively recognition the nucleosides,saccharides,peptides and nitric oxide within the stereo limitation of the postive charged cavity. And trhough the investigation of the machenism andinfluence factor of the recognition behavior, the possible effect of the recogintion progress on the hydrylysis of the nucleoside will be checked. The work will take advantage of the excellent electrical and optic properties of the coordination complex,to constuct the recognition-response channel, to produce the easy-detected signal correspong to the recogintion behavior, to offer a mode for the theoritical study of the research of aritifical high selective enzyme, which will benifit the new target medicine and the research and application of new biosensors. Total 11 papers were published during the three years.
英文关键词: metal organic cages; biomolecular recognition; stereoselectivity;fluorescence;catalysis