经前情感障碍肝气逆、郁两证相关脑区功能定位与脑功能连接特征

项目名称： 经前情感障碍肝气逆、郁两证相关脑区功能定位与脑功能连接特征

项目编号： No.81473558

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 医药、卫生

项目作者： 高冬梅

作者单位： 山东中医药大学

项目金额： 72万元

中文摘要： 我们及美洲精神病学杂志2013年社论研究表明：PMDD发病关键环节与脑中枢关系密切，但涉及哪些主要脑区功能改变及差异脑区间的功能连接特征尚不清楚。 以肝疏泄失常典型病证经前情感障碍肝气逆、肝气逆郁两证为切入点，在前期研究基础上，拟采用BLOD-功能磁共振成像(BLOD-fMRI)和静息状态功能磁共振成像技术， 探寻与该病征发病密切相关的主要脑区功能定位及差异脑区间的功能连接特征，同时比较上述指标有何异同，由此提出PMDD发病关键环节在中枢特定脑区，以前额叶皮质为发病关键脑区且与差异脑区间功能连接异常是其特征；PMDD肝气逆、郁两证调控脑区既有重叠又有差异科学假说。深层次揭示肝疏泄失常发病中枢机制，阐明中医理论的科学内涵，创新肝脏象理论。

中文关键词： 经前情感障碍；肝气逆证；肝气郁证；功能磁共振；功能连接

英文摘要： Our reserch and related study have showed: key link closely of PMDD associated with brain disease ,but which brain functional region chaged will not define. The research will regard catharsis liver disorders leading to typical disease syndrome premesnstrual dysphoric disorder liver-qi sthenia symptom and liver-qi depressed symptom as entry point, will adopt technology of BLOD-fMRI and rest fMRI (rfMRI),to expore positioning related brain regions and positioning of the prefrontal cortex, to analyze functional connectivity of the prefrontal cortex and differences in brain areas with premesnstrual dysphoric disorder liver-qi sthenia symptom and liver-qi depressed symptom,to compare distinctive in the positioning cortexs and functional connectivity both liver-qi sthenia symptom and liver-qi depressed symptom. We shall put forward hypothesis of PMDD key link in the central specific brain regions, to the prefrontal cortex is key brain regions and connected to the differences in brain interval function abnormality is its characteristic; PMDD with liver-qi sthenia symptom and liver-qi depressed symptom, there are differences between the two brain regions is both overlap and the regulation , this will reveal deep liver pathogenesis is central mechanisms, expounds the scientific connotation of TCM theory, liver overthe innovation theory.

英文关键词： premesnstrual dysphoric disorder;liver-qi sthenia symptom;liver-qi depressed symptom;functional MRI;functional connectivity