不对称双面神粒子微探针流变检测仪

项目名称： 不对称双面神粒子微探针流变检测仪

项目编号： No.21303143

项目类型： 青年科学基金项目

立项/批准年度： 2014

项目学科： 数理科学和化学

项目作者： 崔景芹

作者单位： 厦门大学

项目金额： 24万元

中文摘要： 胶体微粒子已广泛作为实验微探针检测黏性或黏弹性流体流变特性等。相比常规流变仪以胶体微粒子作为探针具有样品用量小、测量频率范围广，测量直接，可以还原流体原位真实性质等特点。常见微探针多为追踪球状微粒在介质中的布朗平动，近年来不对称微探针如棒状或盘状粒子的转动或平动加转动也被应用于各流体系统，比单纯平动信息更为丰富。然而这些粒子本身的复杂形状使得数据后处理和数理分析大为繁琐。双面神微球在保持几何形体简单的同时增加了不对称物化特性，其中光学不对称使得微球粒子转动示踪首次成为可能，由是简化示踪分析。本项目拟研制一简洁实用的双面神粒子微探针系统，开发微粒子3D平动－转动图像及数据分析平台，并在此基础上讨论不对称表面修饰对粒子热平动－转动影响，以期获得表面－流体相互作用量化信息。系统可最终用于更精确流变特性分析，以及实时分析反推生物大分子相互作用等与抗体筛选、结合特性、新药开发等相关的重要信息等。

中文关键词： 双面神粒子；微流变；微探针；粒子示踪；图像分析

英文摘要： Colloidal particles have been extensively used as experimental probes for detection of complex fluid, soft matter, or condensed matter dynamics, including viscous and viscoelastic rheology response of fluids, with the benefits of reduced sample amount, much wider frequency range etc. The technique has been mainly focused on translational motion of spherical particles thanks to their abundance and very simple shapes. While rotational dynamics analysis that provides more information has been realized with anisotropic particles (e.g. rods, disks), the non-spherical shape brings in more complicated theoretical analysis, as well as the need of specific equipment in most cases. The optically asymmetric, yet geometrically symmetric and simple Janus particles, on the other hand, gracefully introduce detectable rotational dynamics to a spherical system. Preliminary data showed translational motions of Janus spheres, similar to conventional colloidal probes, were sensitive to fluid viscosity properties under thermal motions. These observations and theoretical simulation indicate Janus spheres are able to provide more insightful, consistent information of rheological properties of liquid mediums, dispersions or complex flows, as well as particle surface-liquid interactions, with less expensive instruments than currently av

英文关键词： Janus particle；microrheology；microprobe；particle tracking；image analysis