蒙药小白蒿燥“希日乌苏”功效与抗炎作用机制的相关性研究

项目名称： 蒙药小白蒿燥“希日乌苏”功效与抗炎作用机制的相关性研究

项目编号： No.81460654

项目类型： 地区科学基金项目

立项/批准年度： 2015

项目学科： 医药、卫生

项目作者： 王青虎

作者单位： 内蒙古民族大学

项目金额： 48万元

中文摘要： 长期以来，在蒙医药学上希日乌苏病方面积累了丰富的治疗方法和传统用药经验，临床疗效显著，并毒副作用小、资源丰富。但目前面临着挑战性的问题就是如何利用现代医学理念来解释蒙医用燥希日乌苏蒙药治疗该病疗效显著的根本原因，即药物在体内的作用机制。本课题选择的蒙药是历代和民间常用的燥希日乌苏 特色蒙药小白蒿。四部医典中阐述了类风湿、风湿、头四肢胸部外伤的病因都是沙日乌苏引起，小白篙能调理血液，兼燥沙日乌苏而治疗关节肿胀。然而，目前很少有科学研究来证实小白蒿这些治疗和药用功效，更谈不上其燥希日乌苏功效与抗炎作用的相关性。本项目从炎症的不同途径和环节对小白蒿总黄酮抗炎及其分子机制进行研究，阐明小白蒿澡希日乌苏功效与其抗炎作用的相关性，确定小白蒿燥希日乌苏功效的关键位点，为解释燥希日乌苏蒙药治疗希日乌苏 病疗效显著的根本原因提供一个新思路和为抗炎蒙药筛选提供一个新方法。

中文关键词： 民族药；有效物质；药理作用；分子机制

英文摘要： For a long time, the traditional medication experience and rich methods of treatment for Xiriwusu disease has been accumulated the traditional Mongolian medicine and pharmacy, which were clinical efficacy, and seldom poisonous effect, rich in resources. But now the challenging problem we have been facing is how to use the concept of modern medicine to explain the root cause of treating significantly the disease with Mongolian medicine possessing the drying Xiriwusu , namely the drug mechanism of action in vivo. Mongolian medicine used in this project is characteristic Mongolian medicine possessing the drying Xiriwusu, Artemisia frigida, which was commonly used in history and folk. The cause of rheumatoid, rheumatism, head and limbs of chest trauma are caused by Xiriwusu and Artemisia frigida can be treatment of arthritis with conditioning blood and drying Xiriwusu in Sibuyidian. However, there is few reported scientific study to support these claimed therapeutic and medical effects, and not to mention the relationship between its drying Xiriwusu efficacy and anti-inflammatory effects. In this project, the anti-inflammatory and its molecular mechanism of total flavonoids from Artemisia frigida are studying in different ways and links of inflammation, and elucidate the correlation of drying Xiriwusu efficacy and anti-inflammatory effects for Artemisia frigida and determine the key site of drying Xiriwusu efficacy for Artemisia frigida, and provide a new idea for explaining the root cause of treating significantly the disease with Mongolian medicine possessing the drying Xiriwusu and a new method for the screening of anti-inflammatory Mongolian medicine

英文关键词： national medicine;active substance;pharmacological action;molecular machanism