意境作业安神解郁作用的ERP效应及分子机制研究

项目名称： 意境作业安神解郁作用的ERP效应及分子机制研究

项目编号： No.81473746

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 医药、卫生

项目作者： 魏玉龙

作者单位： 北京中医药大学

项目金额： 70万元

中文摘要： 心理疾病的危害日趋严重，且发病率逐年上升，社会负担沉重，长效机制应防重于治，故早期心理干预对大学生等高危人群非常重要。前期研究已证明意境作业有明显养心安神作用，本课题选择不同人格有睡眠障碍大学生为研究对象，经过意境作业培训和习练，采用视觉诱发观察意境作业前后ERP早成分和晚成分，结合EEG同步观察α节律、β节律和ERD/ERS，并应用基因芯片技术检测外周血白细胞的全基因组基因表达，并筛选差异基因，以KEGG，GO等数据库及MAS等生物信息软件，观察差异表达基因功能和信号通路，通过与空白对照组对照，比较不同人格人意境作业干预前后ERP与基因表达的差异，探索意境作业训练针对不同人格人发生作用的异同，进而阐明意境作业安神解郁作用的脑功能和分子机制及心身协同性效应机制，为临床预防心理疾病的发病开辟新的途径并提供科学实验依据，丰富中医气功学和中医心理学理论。

中文关键词： 意境作业；ERP效应；分子机制；安神解郁；空白对照

英文摘要： Since the society burden of psychological disease has been aggravated for years running and its morbidity presents a rising tendency, the intervening train in effective mechanism to prevent this kind of disease than to treat in the early stage to be used is a long effective mechanism. On the base of the prophase research about the task of the artistic conception, provided with the obvious effect on meditation to calm the nerves, this research will select the undergraduates as the subjects, after trained and practicing stage by stage by the task of the artistic conception, and observe the early component part and later component part of ERP through visual sense stimulating at the beginning and end period of the task of the artistic conception, and αand βrhythm, and the reaction of ERD/ERS by EEG, and at the same time explore to select the different gene through testing and detecting the genome-wide gene expression profile of peripheral blood leukocyte of the subjects by the application of gene chip technologies, and analysis the different gene's function and signaling pathways using KEGG, GO and MAS biological information database software to find its core function of the molecular mechanism. Through blank control to compare each of the differences of the different personality subjects trained and practicing at the different stages, the research will explore the effect in the similarities and differences of the task of the artistic conception between different personality people, and then clarify ERP effect and molecular mechanism relieving uneasiness of mind and body tranquilization and dispelling melancholy of the task of the artistic conception, therefore to develop a new clinical precaution for psychological disease and provide its experimental basis, rich the theory for Chinese Qigong and Traditional Chinese psychology.

英文关键词： the task of the artistic conception;ERP effect;molecular mechanism;relieving uneasiness of mind and body tranquilization and dispelling melancholy;blank control