逐级靶向高分子纳米药物载体在抗癌药物传输上的应用

项目名称： 逐级靶向高分子纳米药物载体在抗癌药物传输上的应用

项目编号： No.51203153

项目类型： 青年科学基金项目

立项/批准年度： 2013

项目学科： 有机高分子材料学科

项目作者： 肖春生

作者单位： 中国科学院长春应用化学研究所

项目金额： 25万元

中文摘要： 抗癌药物的靶向输运和肿瘤组织的定点释放，是癌症化疗的理想模式，它不仅可以极大提高癌症治疗效果，还可以最大限度地降低药物的毒副作用，提高病人用药的舒适度。高分子纳米载体以其强大的可功能化表面和分子设计带来的功能多样性等优越性能，已被越来越多地应用于抗癌药物的靶向输运和细胞内可控释放，并且已在体外药物释放和细胞水平实验上取得了良好的效果，但其在动物体内的靶向输运和癌症治疗效果却难以令人满意。在本项目中，我们提出以生物相容性良好的PEG和PLLA为材料基础，通过精巧的分子设计，制备具有肿瘤组织环境响应可断裂化学键连接的嵌段共聚物，通过它们的自组装载药，实现同时具有肿瘤组织靶向和癌细胞特异靶向的逐级靶向策略，意在提高高分子纳米载体在体内的靶向药物输运效果；进一步将具有细胞内环境响应可断裂的化学键引入载药体系，从而获得同时具有逐级靶向效果和有效细胞内药物释放的纳米药物载体，有望应用于临床癌症化疗。

中文关键词： 药物输运；肿瘤靶向；纳米载体；刺激响应性；逐级靶向

英文摘要： Targeting delivery and site-directed release of anticaner drug is the ideal pattern of chemotherapy, which can not only enhance the anticancer efficacy but also reduce the possible site-effect with improved comfort toward patient.Polymeric nanocarriers have received increasing interest in the targeting and controlled drug delivery due to their robust functionable surface and diverse molecular functionalities. Though great success have been achieved in vitro, the in vivo targeted delivery and anticaner efficacy of polymeric nanomedicine is far from satisfactory. In the present project, based on biocompatible PEG and PLLA materials, a series of diblock and triblock copolymers with tumor-stie stimuli-sensitive cleavable linkage between the polymer segments are going to be synthesized and investigated to be use as targeted drug delivery. Owing to the detachable micellar shell, the sequential targeting strategy based on the combination of tumor-targeting and cell-targeting could be easily reached, which may improve the targeting delivery of therapeutic agents in vivo.Additionally, we furhter introduce the intracellular stimuli-sensitive cleavable linkage into polymeric micells. The resulting polymeric drug carriers could thus achieve both sequential targeting and site-directed release of drug in the tumor site, which

英文关键词： Drug delivery；Tumor targeting；Nano-carriers；Stimuli-responsiveness；Sequential targeting