有机无机仿生人工骨支架微结构构建过程的工程学

项目名称： 有机无机仿生人工骨支架微结构构建过程的工程学

项目编号： No.21276210

项目类型： 面上项目

立项/批准年度： 2013

项目学科： 化学工业

项目作者： 范代娣

作者单位： 西北大学

项目金额： 85万元

中文摘要： 1.骨支架是目前国际无源医疗器械产品的研究热点之一，无源医疗器械产品的生物学功效取决于支架材料加工过程和支架材料本身。不同的加工过程导致材料的微结构差异很大，从而引起生物学功效的变化。支架的微结构，如孔隙率、平均孔径、孔径分布、弯曲度及其连通性等对细胞的迁移、生长和增殖非常重要。本研究旨在阐释多孔支架构建过程中工程及工艺参数即过程中的热力学和动力学变化引起的支架的微结构、表面化学特性、表面形貌与细胞粘附、迁移、生长和增殖的关系，解释工程控制策略与支架微结构形成的相关性，阐释支架内多尺度孔对骨修复过程的贡献；孔的有序分布与无序分布与软骨、成骨细胞等粘附作用的关系；充分表征其构建过程中工程参数与支架材料的生物学功效、力学强度、降解行为之间的关系。研究不同尺度孔径和孔径分布、比例及孔隙率在组织工程修复中的作用。为工业化生产过程中创制利于组织修复的可行的操作手段和策略的选择提供理论依据。

中文关键词： 类人胶原蛋白；纳米羟基磷灰石；组织工程支架；软骨细胞；生物相容性

英文摘要： Bone scaffolds are the research focus in passive medical instrument field. The bioactive and bio-function of the passive medical instrument mainly depends on the processing and the composition of the scaffolds. Different engineering and technical treatment methods would result in the significant change of microstructure of the scaffolds, of course, leading to the big difference on the bioactive and bio-function observed in clinical test. The microstructure parameters of the scaffolds, such as porosity, average pore size, pore size distribution, flexibility and connectivity, are more important to the cell adhesion, migration, growth and proliferation. The relationship between the cell migration, growth and proliferation and the microstructure, surface chemical characters and surface topography of the scaffolds, resulted from processing and technological parameters, i.e. thermodynamics and dynamics during the processing, would be studied. The target is to reveal the correlation between the engineering control strategy and the microstructure of the scaffolds, the contribution of multi-scale hole to bone-tissue repair, the orderly and disorderly distribution of pores of scaffolds to the cell adhesion function of the osteoblast and the chondrocyte, the relationship between the distribution, proportion and porosity

英文关键词： human-like collagen；nano-hydroxyapatite；tissue engineering scaffold；chondrocyte；biocompatibility