再生纤维素微球的可控制备及结构和性能关系研究

项目名称： 再生纤维素微球的可控制备及结构和性能关系研究

项目编号： No.51303142

项目类型： 青年科学基金项目

立项/批准年度： 2014

项目学科： 一般工业技术

项目作者： 罗晓刚

作者单位： 武汉工程大学

项目金额： 25万元

中文摘要： 再生纤维素微球由于可生物降解和生物相容广泛应用于色谱、分离科学、可控制载体和贮藏体、生物医药和催化剂支撑体、环境和食品等领域。采用传统纤维素溶剂制备微球会造成环境污染，更限制了产品在生物及医学方面的应用；另外采用纤维素衍生物制备微球则难以避免带有残留基团而影响性能。针对这一情况，本项目以NaOH/尿素体系新溶剂直接溶解纤维素用于纤维素微球的制备，并发展新的制备方法；揭示微球的形成机理，制备形貌良好、窄粒径分布的纳米级、微米级和毫米级纯纤维素微球；系统研究纤维素微球的粒径调节和孔形成机理，达到对微球产品的粒径和孔径进行可控调节，并建立对应的数学模型，分析微球产品性能与制备工艺方法的关系；建立纤维素微球产品的表征体系,并揭示纤维素微球的结构与性能的关系，获得综合性能优异的实验室研究用和小规模实用微球样品。为新型纤维素微球的制备方法、结构和性能关系及潜在的生物应用建立提供重要科学数据。

中文关键词： 纤维素微球；尺寸均一微球；可控制备；药物载体；吸附分离

英文摘要： Regenerated microspheres have been widely used in chromatography packing, separation technologies, controlled drug delivery devices, biomedical drug and catalyst carrier, also in the fields of environment protection and food science due to their biocompatibility and biodegradability. However, almost all of these products have been prepared from toxic organic solvent or cellulose derivatives, leaving difficult to eliminate the residues of toxic contaminants and the residual groups or leading the microsphere difficult to wash, which will limit the use of these microsphere products in biological and medical fields. To solve the problems mentioned above, some new methods will be developed to prepare novel plain cellulose microspheres by using the cellulose solution, in which cellulose is directly dissolved in a new "green" cellulose solvent of NaOH/urea solution; cellulose microspheres with good morphology, nano-size or micro-size or millimeter-size, and narrow size distribution will be fabricated by various manufacturing process, and to analysis mechanism of forming microspheres; process of the particle formation and mechanism of pore formation will be analyzed to achieve controllable adjustment of particle size and pore size of the microspheres, and to establish the corresponding mathematical model to analyse the

英文关键词： Cellulose microspheres；Uniform-sized microspheres；Controllable fabrication；Drug carrier；Adsorption and separation