nano-in-micro多功能聚合物微球的可控制备及其在肝癌化疗栓塞疗法中药物可控释放研究

项目名称： nano-in-micro多功能聚合物微球的可控制备及其在肝癌化疗栓塞疗法中药物可控释放研究

项目编号： No.51473057

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 一般工业技术

项目作者： 王芹

作者单位： 华中科技大学

项目金额： 84万元

中文摘要： 经导管肝动脉化疗栓塞（TACE）疗法中存在栓塞和释药行为不可控、药物单一、栓塞微球体内不可视等不足。本项目提出构建一种新型nano-in-micro聚合物微球，其粒径可控且单分散。同时负载超顺磁性氧化铁和多种药物如游离药物和温敏纳米药物，以改善TACE疗效。本项目主要创新点是：基于微流控乳化技术和组装技术，实现nano-in-micro微结构和组成的可控性。其次，包封的超顺磁性氧化铁不仅可增强磁共振成像，在交变磁场作用下其产生的热能还促发微球中温敏纳米载体中药物的释放，实现药物的程序释放和可控释放。同时，其产生的热能可直接杀死肿瘤细胞，具有热疗效果。因此，该体系兼具栓塞、化疗和热疗多重功能。本项目的实施将发展多种多功能聚合物微球、深化微纳结构和多药物释放调控机理研究,具有重要的科学意义；还对开发栓塞、化疗和热疗联合使用的新型肝癌TACE材料提供理论依据和设计方案，因此也具有重要的应用价值。

中文关键词： 微包纳药物载体；微流控；程序释放；化疗栓塞；热疗

英文摘要： There are some shortcomings for the present transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma, such as uncontrollable embolization and drug release behavior, single drug and invisibility of embolic microsphere in the body. To enhance the efficacy of TACE therapy, a novel kind of monodispersed nano-in-micro polymeric microspheres with controllable diameter is proposed, which encapsulates superparamagnetic iron oxide (SPIO) and multiple drugs including free drugs and loaded drugs in a thermosensitive nano-carrier simultaneously. The main innovations of this proposal are as follows. The controllable nano-in-micro microstructure is obtained based on microfluidic emulsion technology and assembly technology. In addition, the encapsulated SPIO not only can enable magnetic resonance imaging detection, but also can generate heat under an alternating magnetic field due to the magnetocaloric effect to trigger the drug release from the thermosensitive nano-carries encapsulated in the microspheres, which achieve a programmable release and controllable release for drugs. As well, the generated heat can kill the adjacent tumor cells. Therefore, this nano-in-micro system combines multiple functions including embolization, chemotherapy and hyperthermia. The implementation of this proposal will develop various multifunctional polymeric microspheres, deepen the study on the micro/nano- structure and controllable release mechanism of multi-drugs. Thus, it possesses important scientific significance. Furthermore, the implementation of this proposal will provide a theoretical basis and design suggestion for the exploitation of novel TACE materials for hepatocellular carcinoma combined with embolization, chemotherapy and hyperthermia. Therefore, it also has great potential application value.

英文关键词： nano-in-micro drug carrier;microfluidic;programmable release;chemoembolization;hyperthermia