二元贵金属多级微纳结构的可控制备、组装及其高灵敏SERS器件的构筑

项目名称： 二元贵金属多级微纳结构的可控制备、组装及其高灵敏SERS器件的构筑

项目编号： No.21475118

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 数理科学和化学

项目作者： 冯九菊

作者单位： 浙江师范大学

项目金额： 90万元

中文摘要： 本项目拟采用溶胶凝胶法、电化学法、水热/溶剂热法等材料合成技术，通过调控分子来控制晶面生长，可控制备二元贵金属多级微纳结构。通过物理或化学修饰技术对其进行改性或功能嫁接。以脱色过氧化酶或漆酶为探针分子来考察材料的拉曼活性，筛选高拉曼活性的二元贵金属多级微纳结构及其合成体系。利用组装、电沉积、滴涂或沉降法等在玻碳、银、金或石英基底表面构筑均一的拉曼活性基底。研究探针分子在拉曼基底上的特征结构、生物活性、增强因子、稳定性、重现性、界面取向、灵敏度等。结合电化学联用技术来研究探针分子的异相电子传递机制和表面催化反应等。探讨材料微观结构与拉曼活性之间的构效关系，建立二元贵金属拉曼器件的 SERS 理论模型，揭示拉曼信号的增强机制。通过该项目发展基于二元贵金属多级微纳结构的高灵敏、高稳定、高重现的拉曼器件，实现底物分子的快速、灵敏、实时和原位检测，并拓展其在环境分析、生化分析和食品分析等领域的应用。

中文关键词： 二元贵金属；多级微纳结构；可控合成；组装；表面增强拉曼光谱

英文摘要： This project would focus on controlled synthesis of hierarchical micro-/nano-structures of noble bimetals by sol-gel, electrochemistry, and hydro(solvo)thermal methods, via tuning the crystal plane growth with the assistance of structure directing agents. These nanostructures can be further modified and functionalized by different chemical and physical methods, and their SERS activities would be examined with decolorizing peroxidase and laccase as Raman probes to select the ones with high-quality and distinctive enhancement. Meanwhile, much work would be conducted for design and fabircation of uniform Raman substrates at glassy carbon, silver, platinum, and quartz supports, using assembly, electrodeposition, casting, or gravity settling technique, followed by investigating the characteristic structures, bioactivity, enhancement factor, stability, reproductibility, interfacial orientation, and sensitivity of the immobilized probes. Furthermore, the heterogenious electron transfer mechanism and interfacial catalysis reaction of the probes would be explored by SERS technique coupled with electrochemistry. Besides, many efforts would be made for the development of a SERS model of the as-prepared nanostructures to have a deep insight on the relationship between the microstructural parameters and the corresponding Raman activity, illustrating their enhanced Raman mechanism. As a result, multi-functional Raman devices with high sensitivity, reproducibility and stability would be designed and constructed for fast, sensitive, reproductive, real-time, and in-situ detection of the probes in bioanalysis, environmental and food analysis.

英文关键词： Noble bimetals;Hierarchical micro/nano-structures;Controlled synthesis;Assembly;SERS