CD25+Foxp3+CD4+和CD25-Foxp3+CD4+Treg在动脉粥样硬化斑块形成中的作用

项目名称： CD25+Foxp3+CD4+和CD25-Foxp3+CD4+Treg在动脉粥样硬化斑块形成中的作用

项目编号： No.30872309

项目类型： 面上项目

立项/批准年度： 2009

项目学科： 金属学与金属工艺

项目作者： 张利宁

作者单位： 山东大学

项目金额： 33万元

中文摘要： 目前有关调节性T细胞（Tregs）的研究主要集中在CD25+Foxp3+CD4+Tregs（CD25+Treg）及其负调控作用上，那么是否有起正向调控作用的Treg亚群的存在，尚不明确。我们在前期研究中发现自身免疫性动脉粥样硬化小鼠和急性冠脉综合症病人中CD25+Treg数量明显降低，但CD25-Foxp3+CD4 +Treg（CD25-Treg）明显升高，最近其他研究者系统性红斑狼疮中也发现类似的结果，这种现象用Foxp3+CD4 +Treg的负调控作用无法解释。因此我们提出CD25-Treg亚群在某些疾病状态下可能起正向调节作用。本课题拟在前期研究基础上，深入研究CD25+Treg和CD25-Treg功能的差异及在动脉粥样硬化斑块形成中的不同作用并探索提高抑制性Treg数量和功能的方法，不仅对全面理解不同Treg亚群的功能特点和与疾病的关系有重要的理论价值，而且也将为动脉粥样硬防治提供新的策略。

中文关键词： CD25-CD4+Foxp3+Treg;CD25+CD4+Foxp3+Treg;动脉粥样硬化;IL-2;CD137抗体

英文摘要： Nowadays,the research about regulatory T cells(Treg) mainly focused on the negative regulations of CD4+CD25+Foxp3+ Tregs(CD25+Treg).It was not clearly whether existed Treg subsets with positive regulation.In our previous studies we found that the number of CD25+Treg reduced significantly in atherosclerotic mice and patients with acute cronary sydrome.However,CD25-CD4+Foxp3+Treg(CD25-Treg) increased obviously.Similarly results have shown in patients with system lupus erythematosus and the negative regulation function of CD25+Tregs could explain this results. So we proposed that CD25-Tregs probably played positive regulation role in some diseases.This issue on the basis of previous studies to indepth study the functional difference between CD25+Treg and CD25-Treg and the effect on the formation of atherosclerotic plaque. We also explored the method to increase the number and function of Treg,this not only had important theoretical value on comprehensive understand the characteristic and the relationship with diseases of different Treg subsets,but also could provied new prevention and treatment strategy for atherosclerosis.

英文关键词： CD25-CD4+Foxp3+Treg;CD25+CD4+Foxp3+Treg;atherosclerosis;IL-2;CD137 antibody