In an effort to provide regional decision support for the public healthcare, we design a data-driven compartment-based model of COVID-19 in Sweden. From national hospital statistics we derive parameter priors, and we develop linear filtering techniques to drive the simulations given data in the form of daily healthcare demands. We additionally propose a posterior marginal estimator which provides for an improved temporal resolution of the reproduction number estimate as well as supports robustness checks via a parametric bootstrap procedure. From our computational approach we obtain a Bayesian model of predictive value which provides important insight into the progression of the disease, including estimates of the effective reproduction number, the infection fatality rate, and the regional-level immunity. We successfully validate our posterior model against several different sources, including outputs from extensive screening programs. Since our required data in comparison is easy and non-sensitive to collect, we argue that our approach is particularly promising as a tool to support monitoring and decisions within public health.
翻译:为了为公共卫生提供区域决策支持,我们设计了一个基于数据的COVID-19疫情隔离模型,该模型适用于瑞典。我们从全国医院统计数据中提取参数先验,并开发线性滤波技术,以根据以医疗需求为形式的数据驱动模拟。我们还提出了一个后验边际估计器,通过参数推导程序提供了改进的繁殖数估计的时间分辨率以及支持鲁棒性检查。通过我们的计算方法,我们获得了一个具有预测价值的贝叶斯模型,该模型提供了重要的见解,包括有效繁殖数估计,感染致死率和地区免疫水平的估计。我们在多个不同来源上成功验证了后验模型,包括广泛的筛查方案产生的输出。由于与我们需要的数据相比易于收集且不敏感,我们认为我们的方法尤其有希望成为支持公共卫生监测和决策的工具。