In this paper, we propose the Adversarial Denoising Diffusion Model (ADDM). The ADDM is based on the Denoising Diffusion Probabilistic Model (DDPM) but complementarily trained by adversarial learning. The proposed adversarial learning is achieved by classifying model-based denoised samples and samples to which random Gaussian noise is added to a specific sampling step. With the addition of explicit adversarial learning on data samples, ADDM can learn the semantic characteristics of the data more robustly during training, which achieves a similar data sampling performance with much fewer sampling steps than DDPM. We apply ADDM to anomaly detection in unsupervised MRI images. Experimental results show that the proposed ADDM outperformed existing generative model-based unsupervised anomaly detection methods. In particular, compared to other DDPM-based anomaly detection methods, the proposed ADDM shows better performance with the same number of sampling steps and similar performance with 50% fewer sampling steps.
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