金属三维打印技术在导航辅助个体化定制下颌骨牵引成骨术中的应用基础研究

项目名称： 金属三维打印技术在导航辅助个体化定制下颌骨牵引成骨术中的应用基础研究

项目编号： No.81470786

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 医药、卫生

项目作者： 蔡鸣

作者单位： 上海交通大学

项目金额： 73万元

中文摘要： 对于复杂的下颌骨畸形和缺损病例，个体化治疗方案与定制的牵引器更符合不同病情的治疗需求，相比于传统方法，能更有效地矫正畸形与修复缺损，减少了手术次数并降低了并发症的发生，有利于提高了疗效。但受限于常规成品牵引器的限制和手术规划与实时操作过程中的不确定性，目前个体化牵引成骨术的应用非常有限。本研究基于前期研究成果，依据电子束熔融成型三维制造技术与导航外科理念，通过计算机辅助设计定制了适合不同下颌骨畸形与缺损的牵引器，应用先进的三维打印技术进行工业制造，并通过一系列实验和测试来验证个体化定制牵引器的精度和可行性。同时借助有自主知识产权的计算机立体定向的导航外科系统平台，将定制牵引器与导航外科技术相结合，准确地将术前规划通过实时导航转移到手术操作过程中，建立专门的术前规划与手术操作方法，并通过一系列模拟手术与动物实验来检验该方法的可行性与精度，目前尚未见相关报道。

中文关键词： 三维打印；手术导航；牵引成骨；计算机辅助；下颌骨畸形缺损

英文摘要： Compare to the triditional mandibular distraction osteogenesis, customize-made distraction device and individualized treatment planning is more efficient for specific clinical cases with complex mandibular deformities and defects. It may reduce the treatment time and incidence of surgical complications. However, the regular distraction devices and planning software could not provide a computer aided customize made mandibular distraction. Currently, based on the 3D printing system, a cusomized diatraction was designed and manufactured. It may reduce the total cost and increase the medical treament outcome. In this project, a three dimensional printing system was introduced, which the material were titanium powder. Combined with electron beam melting 3D printing technique and surgical navigation syatem, a customize made mandibular distraction devices could be planned and manufactured. The continued mandibular reconstruction with systematic continuing research work was based on 3D printing conception. By using 3D printing system combined with surgical navigation technique, a customize made mandibular distratoin devices could be transferred into real time surgery with high accuracy. A serial experiments will be carried out for testing the accuracy and reproducibilities of this technique.

英文关键词： 3D printing;navigation surgery;distraction osteogenesis;computer aided surgery;mandibular deformity and deficiency