肝纤维化多参数MRI与病理形态学改变的定量对比研究

项目名称： 肝纤维化多参数MRI与病理形态学改变的定量对比研究

项目编号： No.81671657

项目类型： 面上项目

立项/批准年度： 2017

项目学科： 医药、卫生

项目作者： 沈文

作者单位： 南开大学

项目金额： 25万元

中文摘要： 肝纤维化是各种慢性肝病所共有的病理改变，可逐渐进展为肝硬化乃至肝癌。在疾病早期及时干预可有效逆转病情，因此其早期诊断对患者的预后尤为重要。近年来，肝纤维化的无创诊断受到极大关注，尽管基于成像原理联合T1rho、体素内不相干运动、扩散峰度和mDXION-Quant的多参数MRI能对肝纤维化的各种病理形态学改变（胶原沉积、扩散改变、灌注改变、铁沉积）进行定量，但二者间的对照研究仅局限于肝硬化，与肝纤维化病理形态学改变间的对应关系尚不明确。据此，本研究拟采集肝纤维化者的多参数MRI数据，联合病理及血清学指标，探讨多参数MRI定量指标与病理形态学改变间的对应关系及对肝纤维化早期诊断的价值；另外，采用治疗后纵向随访的方法，证实其在疗效判断和病情监测中的价值。本研究可望获取肝纤维化形成时出现的早期影像学证据，用于肝纤维化的早期诊断、疗效判断和长期随访。

中文关键词： 肝纤维化；磁共振成像；病理形态学；定量诊断

英文摘要： Liver fibrosis is the common pathological changes of all chronic liver disease. It can develop into cirrhosis and carcinoma. In the early stage of fibrosis, effective therapy can reverse the damage, so the early diagnosis of fibrosis was very important for its prognosis. Recently, noninvasive diagnosis of fibrosis has been intensively discussed. Despite the multi-parameter MRI (T1rho, intravoxel incoherent motion, diffusion kurtosis imaging and mDXION-Quant) based on the principle can quantify the pathomorphological changes of fibrosis (collagen deposition, limited diffusion, perfusion changes, iron deposition), the comparison studies between them were limited to cirrhosis. The relationship between MRI and pathomorphological changes of liver fibrosis was still unclear. Accordingly, this project will collect the multi-parameter MRI findings of patients with liver fibrosis, refer to the pathological and testing results, detect the correspondence between quantitative indicators of MRI and pathomorphological changes, and the early diagnosis value of multi-parameter MRI for liver fibrosis. In addition, this project can reveal the early imaging findings in the progression of fibrosis, and the findings of this project can be used for early diagnosis of liver fibrosis, response evaluation and long-term follow-up.

英文关键词： liver fibrosis;magnetic resonance imaging;pathomorphology;quantitative diagnosis