稀土基上转换纳米复合材料在成像制导的多模式治疗领域的应用研究

项目名称： 稀土基上转换纳米复合材料在成像制导的多模式治疗领域的应用研究

项目编号： No.51472058

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 一般工业技术

项目作者： 杨飘萍

作者单位： 哈尔滨工程大学

项目金额： 83万元

中文摘要： 多功能纳米复合材料在癌症诊断和治疗方面的应用是近年来热点研究课题之一，主要包括多模式成像和化学治疗、光动力治疗(PDT)、光热治疗(PTT)等多种疹疗手段，但也存在一些亟需解决的问题：一是偏重于生物成像研究，成像与治疗彼此分离；二是治疗模式相对单一，多模式协同治疗研究较少，限制了治疗效率；三是不同治疗模式相互作用机制缺乏系统研究。针对这些问题，本项目拟制备一类集上转换荧光、靶向、磁性或介孔等于一体的稀土基多功能复合材料，再通过担载抗癌药物和光敏剂物同时实现化学治疗/光动力治疗/光热治疗等多模式治疗，系统研究不同治疗模式之间的协同作用及相互影响机制。利用上转换荧光成像、磁响应成像(MRI)和CT等多模式成像手段研究复合材料在生物体内的治疗效果，并对其在生物体内的生物安全性展开系统评估,为该类复合材料在癌症诊疗领域的实际应用提供基础研究数据及理论指导。

中文关键词： 上转换发光；光热治疗；光动力治疗；生物成像；生物安全性

英文摘要： The application of multifunctional nanocomposite in the field of cancer diagnosis and therapy has been the research hot spot in recent years, which includes multimodal bioimaging and chemotherapy, photothermal therapy (PDT) and photodynamic therapy (PTT). However, there are still some serious concerns to be resolved. First, the current studies mainly focus on the bioimaging, and there is a separation between the bioimaging and therapy. Second,all kinds of therapies are independent from each other, and the combined application has not been realized, which greatly limit the therapy efficiency. Third, the interaction mechanism between the multimodal therapies has rarely been studied. To solve these problems, the proposal is to design and prepare a series of rare earth based nanocomposites, which combine the functions of up-conversion luminescence,targeting, magnetism and mesoporous structure together. After loading anticancer drugs and photosensitizer, the multimodal therapy (chemotherapy/PDT/PTT) is expected to be realized. Moreover, the synergistic effect and interaction mechanism between each therapy is also to be investigated systematically. After that, the curative effect of the multimodal therapy in cells and mice will be evaluated by the multimodal bioimaging (up-conversion/MRI/CT) based on the mulfunctional properties of the nanocomposites. The biological safety of as-prepared nanoccomposites in variou cells and living bodies will also be systematicallly studied based on a series of tests, in order to provide the basic research results and theoretical guidance for the clinic application of this kind of functional nanocomposites in cancer diagnosis and therapy.

英文关键词： up-conversion luminescence;photothermal therapy;photodynamic therapy;bioimaging;biological safety