基于具身认知的动作词句加工对脑卒中运动功能的调控及多维动态脑机制

项目名称： 基于具身认知的动作词句加工对脑卒中运动功能的调控及多维动态脑机制

项目编号： No.81472163

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 医药、卫生

项目作者： 单春雷

作者单位： 上海中医药大学

项目金额： 72万元

中文摘要： 神经科学、心理学、语言学研究热点- - 具身认知加工领域中来自正常人的研究证据支持语言加工建立在运动控制脑网络之上，语言加工和运动彼此偶联并双向影响。近几年有研究证实动作观察对脑卒中失语症患者语言功能促进，但语言加工是否促进偏瘫肢体运动功能？尚无答案。本项目组预实验发现动作词（如举手）语义加工对脑卒中患者偏瘫上肢的运动反应有即刻促进作用；功能性磁共振、事件相关电位预实验初步证实动作词加工引起前运动皮质和后顶叶等关键运动控制区激活；动作词加工使经颅磁刺激初级运动皮质的运动诱发电位显著增高。然而，动作词/句加工对偏瘫肢体运动功能具体有何调控作用？对应的脑机制如何？都值得进一步研究。本项目将利用行为学、脑成像、脑电和肌电技术，深入探索动作词/句加工对偏瘫肢体运动功能的调控作用和动态脑机制，为脑卒中偏瘫肢体康复提供创新方法，为具身认知理论提供病理证据，有着广阔的应用前景和重要的理论意义。

中文关键词： 具身认知；脑卒中；语言加工；运动功能；脑机制

英文摘要： Embodied cognition has been the focus of neuroscience, psychology and linguistics. Evidence from healthy subject studies have indicated that language processing is based on brain networks for motor control and language and motor processing couple together and influence each other. Recently, a lot of studies have confirmed that action observation improve the language function of stroke patients with aphasia. However, it has not yet been known that whether language processing can promote motor function of hemiplegic limb.Our preliminary experiments show that semantic processing of action words (such as raise hand) has immediate effect on the motor reaction of hemiplegic upper limb in stroke patients. Our functional magnetic resonance imaging (fMRI) and event related potentials (ERP) pre-experiments have confirmed that action words processing may activate the key motor control cortex such as premotor and posterior parietal cortex. Meanwhile, action words processing increases the motor evoked potential (MEP) significantly when using single pulsed transcranial magnetic stimulation (TMS) to stimulate the primary motor cortex(M1). Nevertheless, how about the specific modulation role of action words/sentence processing on motor function of hemiplegic limb? And how about the mechanism of this modulation effect？Both key questions need further studies to answer.In our project, we will adopt integrated techniques including behavioral, brain imaging, electroencephalogram and electromyography experiments to explore the distinct modulation effects of action words/ sentence processing on motor function of hemiplegic limb of stroke patients and the corresponding brain mechanisms. Implementation of this project will has broad application prospects and important theoretical significance not only for providing the innovative treatment approaches for functional rehabilitation of hemiplegic limb, but also for providing the pathological evidence for embodied cognition theory.

英文关键词： embodided cognition;stroke;language processing;motor function;brain mechanism