血管源性认知障碍产生及功能补偿的神经机制研究

项目名称： 血管源性认知障碍产生及功能补偿的神经机制研究

项目编号： No.31271061

项目类型： 面上项目

立项/批准年度： 2013

项目学科： 生物科学

项目作者： 徐进

作者单位： 西安交通大学

项目金额： 80万元

中文摘要： 血管源性认知障碍（VCI）涵盖了血管源性认知损害从轻到重的整个发病过程，其中轻度VCI（mVCI）是血管性痴呆（VD）的前期阶段，是阻止和延缓VD产生的最佳时机。本项目以mVCI为主要研究对象，首先拟从功能连接、信息流等角度对mVCI执行注意障碍的产生机制和功能补偿机制进行探索研究，采用非线性同步测量方法构建执行注意网络的动态功能连接模型，利用有向传递函数明确网络节点间的因果关联性。其次，从网络拓扑属性角度寻找mVCI与VD的统计学差异，提取出可灵敏反应mVCI开始转化为VD的预警标志。本研究采用先进的EEG和fMRI多模态信息融合技术，对所提出的研究内容进行深入系统地研究，其成果将有助于增进人们对血管源性认知障碍产生机制和功能补偿机制的认识，更有助于mVCI临床的早期诊断和干预治疗，从而降低VD的发病率。因此本项目具有重要的理论意义和很好的应用价值。

中文关键词： 血管源性认知障碍；脑电；功能连接；脑网络；信息融合

英文摘要： Vascular cognitive impairment (VCI) was proposed as an umbrella term to include subjects affected with any degree of cognitive impairment resulting from cerebrovascular disease (CVD), ranging from mild vascular cognitive impairment (mVCI) to vascular dementia (VD). mVCI is the preceding period of VD, which is also the best period to prevent and delay developing process of VD.The research focuses on mVCI patients. First, we study on pathogenesis of executive/attentive impairment and functional compensatory mechanism in mVCI patients by functional connectivity analysis and information flow method. As well as, the dynamic model of functional connectivity will be built with nonlinear synchronization methods，and causality between brain nodes will make clear by directed transfer function (DTF) analysis for executive/attentive network. Second, remarkable difference will be found in network properties, and the marks used to forecast when mVCI patients begin to change in VD will be extracted. Advanced technology in multi-modal information integration based on EEG and fMRI data is used in research work. The findings would help people to understand the pathogenesis and functional compensatory mechanism of mVCI, and also be helpful for early diagnosis and treatment of mVCI, and reduce incidence rate of VD in clinic. Theref

英文关键词： vascular cognitive impairment；EEG；functional connectivity；brain network；information integration