有机阳离子柱撑磷酸盐的组装及长效抗菌活性研究

项目名称： 有机阳离子柱撑磷酸盐的组装及长效抗菌活性研究

项目编号： No.20871058

项目类型： 面上项目

立项/批准年度： 2009

项目学科： 化学工业

项目作者： 谭绍早

作者单位： 暨南大学

项目金额： 33万元

中文摘要： 本项目设计一种有机阳离子柱撑磷酸盐的新型有机-无机复合抗菌材料，重点研究其组装、结构控制和长效抗菌活性。先合成层状磷酸盐，再通过助剂使其层间距增大而获得前驱体，然后将有机阳离子组装至层间形成稳定的柱撑化合物。系统研究磷酸盐和极性小分子种类、胶体化处理工艺对前驱体组成结构，以及前驱体组成结构、有机阳离子种类和插层工艺对柱撑化合物组成结构的影响规律，探索插层反应机理，获得可控结构的柱撑化合物；深入研究柱撑化合物组成、结构形态、表面状态（荷电性、疏水性和吸附性等），有机阳离子形态分布与抗菌活性的内在关系，揭示抗菌活性产生机制；进一步探索柱撑化合物组成结构与稳定性（耐热性、耐光性和溶出性）的相互关系及规律，构建柱撑化合物长效抗菌活性的关键结构模型。本项目研究处于学科前沿，其研究成果对于提高我国抗菌材料基础研究水平，发展一类新型抗菌材料，推动我国化学化工、材料、物理和微生物学等学科发展具有重要意义。

中文关键词： 有机阳离子; 柱撑磷酸盐; 组装; 结构控制; 长效抗菌活性.

英文摘要： In this item, a kind of novel antibacterial material of inorganic-organic composites containg organic cations pillared phosphates is desinged, and the assembly, structural control and long-term antibacterial activity of the antibacterial material are emphasized. Layered phosphates are firstly prepared, and then precursors are obtained by enlarging the interlayer spacings through accessory ingredients. Finally, stable pillared compounds are synthesized by assembling organic cations into the interlayers of the precursors. Effect of the types of phosphates and small polar molecules, and the colloidizing processes on the component structures of the precursors, and that of the component structures of the precursors, the types of organic cations and the intercalation processes on the component structures of the pillared compounds are systemically discussed, and the intercalation reaction mechanism is explored, thus the pillared compounds with controllable structures are attained. The internal relation of the antibacterial activity with their components, structure morphologies, surface states (charges, hydrophobicities, adsorption properties, etc), and the arrange-styles and distributions of organic cations are deepley studied, and then the excitation mechanism of the antibacterial activity is revealed. The interrelation and regularity of the component structures of the pillared compounds with their stability (heat resistance, light permanency, stripping property) are made further investigation, and the key structure models of the pillared compounds with high stability and good antibacterial activity (long-term antibacterial activity) are designed. This study, located in a frontier course, plays vital role in raising nation's basic research level of antibacterial materials, developing new types of antibacterial materials, and promoting the courses of chemistry and chemical industry, materials science, physics, microbiology, and so on.

英文关键词： Organic cations; pillared phosphates; assembly; structural control; long-term antibacterial activity.