基于光学分辨模式的便携式实时光声显微成像技术研究

项目名称： 基于光学分辨模式的便携式实时光声显微成像技术研究

项目编号： No.11304129

项目类型： 青年科学基金项目

立项/批准年度： 2014

项目学科： 数理科学和化学

项目作者： 曾吕明

作者单位： 江西科技师范大学

项目金额： 30万元

中文摘要： 光学分辨式光声显微成像（OR-PAM）结合了纯光学成像的高对比度和纯声学成像的高穿透性优点，近年来在空间分辨率、成像速度、探测灵敏度和探测深度等方面取得了显著进展。但由于常用的光声激励源--固体激光器具有价格高、体积大、需冷却、维护难等缺点，使得OR-PAM系统难以集成一体化而走出实验室。作为一种新型的光声激励源，半导体激光器--激光二极管具有价格低、体积小、重复率高等优点，并已探索性用于光声成像领域。2012年，本申请人提出基于激光二极管辐射源的三维可视化光声技术[Opt.Express, 20(2),2012]，并开发了第一代的便携式OR-PAM样机系统[Appl.Phys.Lett.102(5),2013]。现计划在此基础上，采用激光振镜扫描激发、多元阵列式传感、多通道并行采集、动态相控聚焦合成、三维可视化重建等技术，建立健全一套无损、便携、实时和高分辨率的光声显微成像系统及其方法。

中文关键词： 光学成像；超声成像；显微成像；无损检测；图像重建

英文摘要： Optical-resolution photoacoustic microscopy (OR-PAM) combines the advantages of high absorption contrast of pure optical imaging and high penetration depth of pure ultrasound imaging, which has been significantly improved in terms of spatial resolution, imaging speed, detection sensitivity and depth. However, thus far, most OR-PAM systems generally utilize bulky solid-state lasers for optical illumination, which makes them inherently difficult to achieve integrative producibility, because of their high cost, large size, cooling requirements, and complex maintenance. As an alternative laser source, semiconductor excitation of laser diodes are relatively inexpensive, compact, and high repetition frequency for noninvasive photoacoustic equipment, which has been explored for photoacoustic imaging studies. In 2012, we has presented the 3D-visual photoacoustic imaging technique with a laser diode excitation [Opt.Express,20(2),2012], and recently design the first generation portable OR-PAM prototype [Appl.Phys.Lett. 102(5),2013]. Therefore, we are planning on this basis to integrate the following techneques of laser galvanometer scanning excitation, multielement array detection, multichannel parallel acquisition, dynamic phase-controlled focus synthesis, and 3D-visual reconstruction, etc., and devote to develop a nonin

英文关键词： optical imaging；ultrasonic imaging；microscopy；nondestructive testing；imaging reconstruction