不对称卟啉化合物合成过程中传递及分离规律研究

项目名称： 不对称卟啉化合物合成过程中传递及分离规律研究

项目编号： No.21276006

项目类型： 面上项目

立项/批准年度： 2013

项目学科： 化学工业

项目作者： 佘远斌

作者单位： 浙江工业大学

项目金额： 83万元

中文摘要： 针对目前不对称卟啉化合物合成过程中因反应快、不同底物醛扩散、传递速度差小而难以控制、且反应规律不清导致产物选择性差、收率低，产物分离纯化困难的问题，本项目旨在通过调控不同反应物醛的扩散速度，形成梯度传递来影响其与吡咯的反应速度，调控不同底物之间的反应速度，大幅度地提高不对称卟啉的合成收率。同时通过选择合适的分离柱，实现产物的梯度分离，进一步提高目前产物的分离收率，探讨规模化制备不对称卟啉化合物的规律；重点研究多种醛与吡咯发生缩合规模化制备不对称卟啉化合物的核心科学问题- - 原料醛的结构和扩散速度与卟啉产物选择性和收率之间的关系，通过调控传递和分离速度，实现不对称卟啉的规模化合成，以期大幅度地提高不对称卟啉产物的选择性和收率，并使其分离纯化更加简单、有效。通过梯度扩散反应和分离方法提高产物收率的研究尚未见文献报道，且研究结果将对不对称卟啉高收率的规模化合成提供重要的基础数据和理论依据。

中文关键词： 不对称卟啉；合成；分离；仿生催化；金属卟啉

英文摘要： Contraposing some problems presently existing in the rapid synthetic reactions of asymmetric porphyrin compounds such as poor product selectivities,low yields and difficult separation and purification due to the diffusion of different substrates, less disparity in transfer velocities of different substrates and unclear transfer rules, the objectives of this project will aim at improving the diffusion rates of different reactant aldehydes and forming a gradient transfer to affect the reaction speeds of aldehyde and pyrrole. Thus, the reaction speeds of different substrates will be effectively controlled and the synthetic yields of asymmetric porphyrins will increase greatly. At the same time, the rapid and gradient separation will be realized by selecting the appropriate separatory columns. And further, the separation yields of target products will be improved and the synthetic rules in large-scale preparation of asymmetric porphyrins will be deeply investigated. The core science problems of large-scale synthesizing asymmetric porphyrins with the condensation of various aldehydes and pyrrole including the relationship between the structures or diffusion velocities of reactant aldehydes and the reaction activities, selectivities and yields of products will be emphatically investigated. By effectively controlling t

英文关键词： asymmetric porphyrin；synthesis；separation；biomimetic catalytic；metalporphyrin