功能性便秘导致精神障碍的脑肠交互作用机制的影像学研究

项目名称： 功能性便秘导致精神障碍的脑肠交互作用机制的影像学研究

项目编号： No.81470816

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 医药、卫生

项目作者： 张毅

作者单位： 西安电子科技大学

项目金额： 73万元

中文摘要： 便秘发病率高达16%，已成为影响人们生活质量的重要因素之一。便秘可导致抑郁焦虑等精神障碍，精神因素反之加重便秘，但便秘患者脑肠之间异常交互作用机制尚不明确。申请人课题组对便秘导致精神障碍患者的功能影像初步研究发现中枢运动控制与躯体感觉反馈和情绪唤醒网络存在功能异常，这种功能性改变是否就是通过脑肠轴引起便秘患者肠道动力障碍，最终导致便秘的原因，便是本课题研究假设。研究中将采用功能磁共振成像，针对功能性便秘导致精神障碍的患者，从脑肠交互和临床治疗两方面研究便秘导致精神障碍的脑肠交互作用机制。主要利用多模态成像建立功能性便秘导致精神障碍的脑肠交互因果作用模型；结合临床与影像数据，研究大脑结构功能变化与便秘症状之间的相关性；确立功能性便秘分型对应的大脑特征区域；通过肠道干预和精神药物治疗，研究其对脑肠交互的干预机制。本项多学科交叉研究将为便秘传统治疗和抗精神干预的联合治疗提供理论支持和临床指导。

中文关键词： 功能性便秘；精神障碍；功能磁共振成像；情绪唤醒网络；脑肠交互

英文摘要： The incidence of constipation is as high as 16%, it has become one of the important factors that affect the quality of our life. Constipation can lead to depression, anxiety and other mental disorders, while mental factors aggravate constipation and vice versa. The interactive mechanism between brain and gut is not clear. Our functional magnetic resonance imaging (fMRI) pilot study of constipation causing mental disorders revealed abnormal brain activities of motor and somatosensory areas and the emotional arousal network, thus whether such functional alterations causing intestinal motility disorders through the brain-gut axis and eventually leading to constipation is the hypothsis of the present study. The current study will utilize fMRI and patients with functional constipation (FC) associated with psychological disorders to investigate the brain-gut interaction underlying FC causing mental disorders from the perspectives of the brian-gut interaction and clinical treatments. Firstly, we will establish a brain-gut interactive causal influence model of FC causing mental disorders using multi-modality imaging, and study the correlation between the alterations of brain structure and function and symptoms of FC by combining clinical and imaging data. Secondly, we will characterize relationship between FC subtype and their corresponding brain regions. Finally, we will study the intervention mechanism of brain-gut interaction through the intestinal tract intervention and mental therapy. The current cross-cutting multidisciplinary study will provide theoretical support and clinical guidance via traditional and a combination of psychological intervention treatiments of FC.

英文关键词： Functional Constipation;Mental Disorders;fMRI;Emotional Arousal Network;Brain-Gut Interaction