氨基酸与离子液体的相互作用及萃取分离性能研究

项目名称： 氨基酸与离子液体的相互作用及萃取分离性能研究

项目编号： No.21303044

项目类型： 青年科学基金项目

立项/批准年度： 2014

项目学科： 数理科学和化学

项目作者： 陈玉娟

作者单位： 河南师范大学

项目金额： 25万元

中文摘要： 离子液体在氨基酸的萃取分离方面具有特有的性能，为了优化和调控基于离子液体的氨基酸分离和提纯方法，认识氨基酸+离子液体双水相体系的成相规律，研究离子液体与氨基酸之间相互作用便显得尤为重要。本项目拟利用量热、体积、电化学、粘度和电导等宏观方法并结合NMR技术、分子动力学模拟和量化计算等微观手段，系统研究氨基酸与离子液体在水溶液中相互作用的规律及微观机制。探索离子液体与氨基酸相互作用与氨基酸分子立体结构及离子液体结构和性质的依赖关系，确定它们相互作用的基团和位点。研究氨基酸+离子液体双水相体系的成相规律、微观结构及其对生物分子萃取分离性能的影响。研究结果对于解释生物体液中氨基酸-离子液体相互作用的本质具有重要的科学意义；为研究离子液体在生物体内的潜在毒性提供基础数据；为调控生物分子的萃取分离和建立基于离子液体的氨基酸绿色分离方法提供理论指导。

中文关键词： 离子液体；氨基酸；热力学；微观结构；双水相

英文摘要： The extraction/separation techniques of amino acids by ionic liquids present higher performance, and have aroused increasing applications. In fact, to optimize and control the separation and purification of amino acids by ionic liquids from aqueous media, and to explore the equilibrium of aqueous biphasic systems formed by ionic liquids and amino acids, the knowledge of their physicochemical and thermodynamic properties is required. In this program, combined with NMR spectroscopy, molecular dynamic simulation and quantum chemical calculation, we will use macrophysicochemical methods, such as calorimetry, volumetry, electrochemistry, viscosity and conductivity, to investigate systemically the interactions between ILs and amino acids, as well as micro-mechanism of these interactions. Based on the measured data and calculated results, we will explore the dependences of the interactions on the stereochemical structure of amino acids and ILs, and evaluate the groups and sites of amino acids linkages which interact with ILs. With the macroscopical and microscopic methods, we investigate the equilibrium and microscopic structure of aqueous biphasic systems formed by ionic liquids and amino acids, and the extraction of biomolecules. Results thus-obtained will be very significant to interpret the interaction between amin

英文关键词： ionic liquids；amino acids；thermodynamics；microstructure；aqueous two-phase systems