原络配穴协同调节偏头痛患者痛感受和痛情绪的脑基底节-皮层环路机制研究

项目名称： 原络配穴协同调节偏头痛患者痛感受和痛情绪的脑基底节-皮层环路机制研究

项目编号： No.81473603

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 医药、卫生

项目作者： 赵凌

作者单位： 成都中医药大学

项目金额： 69万元

中文摘要： 在已完成的国家自然科学基金中，项目组采用脑功能成像技术，初步得出原络配穴针刺对偏头痛患者脑内神经信息调节强度比非原络配穴强，可调节前扣带回-脑岛局部功能网络。本项目在此基础上，紧密围绕原络配穴针刺产生协同效应，改善偏头痛患者痛感受和痛情绪的关键环节是对脑基底节-皮层环路结构、功能和受体水平的特异性调节的工作假说，以偏头痛患者为研究对象，从原络配穴协同效应入手，以痛感受和痛情绪为突破口，融合结构功能MRI和受体PET成像技术，从脑结构、脑功能和脑受体3个层次进行定性、定位和定量分析；依托针灸学、神经影像学、生物医学工程、分子生物学等多学科技术手段，研究原络配穴针刺与原穴、络穴和非穴比较，对偏头痛患者从临床效应-神经递质-中枢环路的特异性影响模式，深入挖掘原络配穴协同效应与单独针刺原穴、络穴对应的脑基底节-皮层环路调节模式的异同和相关性，阐释原络配穴协同效应产生的科学内涵。

中文关键词： 原络配穴；偏头痛；针刺；分子影像；基底节-皮层环路

英文摘要： Our previous NSFC program concluded the primary finding that Yuan-Luo acupoints combination exerts a higher impact on the intracranial neuroinformatics processing system than its nil control, it's capable of modulating the local anterior cingulate cortex(ACC)-insula functional network. Based on this, we further raise the hypothesis that 'Yuan-Luo acupoint combination yields integrative effect, the key of that to benefit migraineurs through regulating their pain perception and emotional distress of pain is the specific modulation to the structure, function and receptors of basal ganglia-cortical loop'. Featuring on the pain perception and emotional distress of pain, this study focuses on the integrative healing effect of Yuan-Luo acupoint combination for experimental subjects, chronic migraineurs. We would like to conduct qualitative, locational, and quantitative analyses on three different levels as brain structure, brain function, and cerebral receptors, respectively, by integrated functional and structural MRI and receptor PET imaging technology. The technological organization of multiple disciplinary research domains such as acupuncture, neuroimaging, biomedical engineering, and molecular biology, equipped us to basically compare Yuan-Luo acupuncture with Yuan acupoint, Luo acupoint, and non-acupoint, respectively, and to investigate its specific influential pattern on clinical efficacy, neurotransmitters, and central circuit of acupuncture for migraineurs. This study may provide us further evidence to deepen and widen our knowledge on the differences and similarities, and their correlations of Yuan-Luo acupoint combination, single Yuan acupoint, and Luo acupoint, in their effect on related brain basal ganglia-cortical loop, and therefore it could elucidate the scientific connotation of the integrated effect of Yuan-Luo acupoint combination.

英文关键词： Yuan-Luo acupoints combination;migraine;acupuncture;molecular imaging;basal ganglia-cortical loop