生物体微细结构内纳米颗粒输运机制和热物理效应

项目名称： 生物体微细结构内纳米颗粒输运机制和热物理效应

项目编号： No.51276013

项目类型： 面上项目

立项/批准年度： 2013

项目学科： 能源与动力工程

项目作者： 乐恺

作者单位： 北京科技大学

项目金额： 80万元

中文摘要： 纳米生物医学的发展对促进人类健康具有巨大推动作用，微细尺度下纳米颗粒与生物体相互作用的研究具有重要的科学意义和实际应用价值。本项目通过深入观测和认识毛细血管及细胞区等微细结构内纳米颗粒的能质传递现象，探析纳米颗粒-纳米颗粒、纳米颗粒-生物体间相互作用机制，揭示纳米颗粒在微细结构中输运和能量传递机制及其耦合作用，建立微/纳尺度下纳米颗粒在毛细血管中流动、跨血管壁和跨细胞膜输运以及细胞层次能量传递的数理描述，并探究微尺度能质传递与宏观现象的关联规律及影响因素。旨在有效预测纳米颗粒输运和分布规律、微细结构内温度分布及演变规律，并针对纳米颗粒特性与外激励场施加方式提出优化调控方案。本研究将为成功实现纳米生物医学的临床应用奠定基础，为掌握纳米粒子对人类健康的影响等提供科学理论依据。

中文关键词： 生物体；微/纳尺度；纳米颗粒；热物理效应；输运

英文摘要： The development of nano-biomedical science plays a significant role in promotion of human health. A good understanding of the interaction mechanism between nanoparticles and biology tissue is greatly meaningful both for scientific theory and practical application. Through the deep observation and investigation on heat and mass transfer phenomenon in micro biology structure, such as capillary and cell, the objective of this study is to understand the interaction mechanism of nanoparticles-nanoparticles and nanoparticles-biology tissue. Specifically, this study is attempting to determine the mass and heat transfer mechanism of nanoparticles in micro-structure and the coupled effect, and to establish the physical and mathematic models for the mass and heat transfer processes, including the delivery of particles in capillary and permeation of nanoparticles through the capillary wall and cell membrane. Furthermore, the study is trying to analyze the crucial influencing factors of these processes and set up the relationship of heat and mass transfer at the micro-scale with the phenomena at the macro-scale. This study project is aiming at achieving an efficient method to predict the transport and distribution of nanoparticles and temperature distribution in the micro-structure of living body. Moreover, an optimized con

英文关键词： living body；micro/nano scale；nanoparticle；thermophysical effect；transport