980nm激光驱动纳米发电机的设计、构筑及其生物应用

项目名称： 980nm激光驱动纳米发电机的设计、构筑及其生物应用

项目编号： No.51272299

项目类型： 面上项目

立项/批准年度： 2013

项目学科： 一般工业技术

项目作者： 陈志钢

作者单位： 东华大学

项目金额： 80万元

中文摘要： 无线纳米生物器件将为生物医药领域带来革命性的变化，其发展前提是研发适用于生物体系的纳米电源。本项目旨在开发生物兼容的980nm激光驱动纳米发电机(980LDNG)，主要研究内容包括：(1)设计和制备两类柔性上转换发光纳米复合电极；第一类是柔性平板状复合电极，即通过在柔性透明导电衬底上制备光电活性-稀土上转换发光材料的双层或者共混单层膜；第二类是柔性纤维状复合电极，先利用静电纺技术制备上转换发光稀土纳米纤维，再以纤维为衬底依次制备导电层和光电转换活性层。(2) 将两类柔性电极分别组装成980LDNG，并以980nm激光作为驱动力，测试980LDNG的光电性能。(3)探索980LDNG中能量转移以及光生载流子拆分和传输规律，优化和遴选高效的980LDNG，并研究其与生物体系的相互影响；最后探索其作为新型生物电源在纳米生物器件中的应用。本项目将为新型生物电源的研制和纳米生物器件的发展奠定基础。

中文关键词： 近红外光；纳米发电机；光热转换材料；生物医学应用；

英文摘要： Wireless nanobiodevices (such as nanorobots) have great potential to revolutionize the diagnosis and therapeutic system for human health, but their use has been limited by difficulties in fabricating such nanobiodevices, and one of difficulties is to obtain an in-vivo energy source as their biopower component. To address this problem, this project aims to develop biocompatible 980-nm-laser-driven-nanogenerators (980LDNGs) as the in-vivo electrical source, and it consists of three steps. The first step is to design and prepare two kinds of flexible nanostructured electrodes with efficient up-converting luminescence. One kind is flexible flat nanostructured electrode, which will be prepared by depositing photoactive material/rare earth upconverting nanophosphor double-layers or mixed single-layer on flexible transparent conducting substrate. The other kind is flexible fiber-shaped nanostructured electrode, which will be obtained by fabricating rare earth upconverting nanofibers via the electrostatic spinning route and subsequently depositing transparent conducting layer and photoactive layer on the nanofibers. The second step is to use flexible nanostructured electrodes with up-converting luminescence to construct 980LDNGs, and then measure their photoelectric performances under the irradiation of 980 nm laser. Th

英文关键词： NIR light；nanogenerators；photothermal nanoagents；biomedical applications；