基于新型二茂铁衍生物功能化石墨烯/纳米材料修饰电极的电化学传感研究

项目名称： 基于新型二茂铁衍生物功能化石墨烯/纳米材料修饰电极的电化学传感研究

项目编号： No.21305042

项目类型： 青年科学基金项目

立项/批准年度： 2014

项目学科： 数理科学和化学

项目作者： 刘美玲

作者单位： 湖南师范大学

项目金额： 25万元

中文摘要： 二茂铁及其衍生物是优良的电子媒介体，被广泛用于构建高灵敏的化学/生物传感器。但小分子媒介体易泄露和流失，故如何将二茂铁固定于电极表面以获得性能稳定的电化学传感器是该领域研究的难点之一。本项目拟通过交叉偶联等反应设计并合成系列二茂铁乙炔类化合物，利用共价键合作用等制备二茂铁功能化石墨烯，构建信号双重放大的检测平台，探索其在电化学传感中的应用。主要内容包括：1）设计合成含氨基/醛基/硫脂基/羧基等官能团的二茂铁乙炔衍生物；2）通过共价键合或者共轭基团与石墨烯的π-π堆积作用,制备不同的二茂铁衍生物功能化的石墨烯；3）利用二茂铁衍生物的电子媒介/催化作用和纳米材料的催化放大作用，实现对单组分和多组分电活性酚类物质的双重放大检测。该课题的研究可望建立新型二茂铁衍生物和二茂铁衍生物功能化石墨烯的制备方法和电活性小分子的高灵敏检测新方法，为二茂铁衍生物的合成、优选、固定和应用提供新思路。

中文关键词： 二茂铁衍生物；石墨烯；碳纳米材料；信号放大；电化学检测平台

英文摘要： Ferrocene and its derivatives are electroactive electron mediators and have been widely used in fabricating chemo/biosensors with high sensitivity. However, the mediators are easily leaked from the biosensors and therefore, how to synthesize newly special ferrocene derivatives and immobilize them on electrode to obtain excellent biosensors is a challenge for researches.This program is aim to design and synthesize serials of ethynylferrocene terminated oligo(p-phenylene ethynylene)s compounds, and combined the nanotechnology to prepare ferrocene functional graphene nanocomposites. The graphene-based composites then will be fabricated as doublely signal amplifying platforms to be utilized in chemo/biosensors. The main contents are: 1) Design and synthesize series of ethynylferrocene derivatives with different functional groups, such as -NH2,-CHO,-SOOCH3,-COOH and so on; 2) Prepare the ferrocene functional graphene nanocomposite through the covalent bonding and π-π stacking interaction between the ferrocene derivatives and graphene nanomaterials; 3) Construct doubly amplifying platform for detection of single or multiple phenols based on the synergy amplifying effect of the electron mediators of ferrocene derivatives and graphene and metal nanoparticles.This program is hopeful for constructing new methods for immob

英文关键词： Ferrocene derivatives；graphene；carbon nanocomposites；signal amplifying；electrochemical detection platform