金山五味子治疗阿尔茨海默症活性成分及机制

项目名称： 金山五味子治疗阿尔茨海默症活性成分及机制

项目编号： No.31270394

项目类型： 面上项目

立项/批准年度： 2013

项目学科： 生物科学

项目作者： 阮汉利

作者单位： 华中科技大学

项目金额： 80万元

中文摘要： 阿尔茨海默病(AD)是严重危害老年人身体健康的神经退行性疾病，β淀粉样蛋白(Aβ)在其发病过程中起关键作用，减少Aβ产生或加快其清除已成为AD治疗新策略。作用于分泌酶的药物能从源头上减少Aβ产生，从而根本上阻止AD发展，因此成为AD治疗最有希望的靶点。金山五味子产于湖北西部和四川中南部，民间用其果实治疗心悸失眠、自汗盗汗等症，用其藤茎治疗风湿痹痛、神经衰弱等。前期研究结果显示，金山五味子藤茎和果实提取物均具良好的抑制Aβ42产生及神经保护作用，进一步跟踪分离从金山五味子藤茎得到多种四氢呋喃型和二芳基丁烷型木脂素类成分，且部分木脂素类化合物能显著抑制Aβ42产生，并对氧化损伤和缺氧损伤的SH-SY5Y细胞具保护作用。本课题拟以Aβ及其形成过程中的α，β和γ分泌酶及其它相关物质为靶点，对金山五味子藤茎和果实分别进行深入的抗AD活性成分筛选及机制研究，以期寻找高效低毒抗AD先导化合物。

中文关键词： 金山五味子；五味子属；阿尔茨海默病；神经保护；木脂素

英文摘要： Alzheimer's disease (AD) is a degenerative brain syndrome characterized by a progressive decline in memory, thinking, comprehension, calculation, language, learning capacity and judgment sufficient to impair personal activities of daily living. More than 25 million people in the world suffer from Alzheimer's disease and as many as 8 million Chinese are living with AD. Alzheimer's destroys brain cells, causing problems with memory, thinking and behavior severe enough to affect work, lifelong hobbies or social life. Prevention and treatment of AD has attracted the widespread concern of the society. The discovery of new anti-AD lead compounds and its mechanism study is becoming an important topic for the scientists. Beta amyloid protein (Aβ) forms plaque in which proteins are accumulated and aggregated in brain, and thus has a causal role in the pathogenesis of AD. Therapeutics targeting α,β,γ-scretases could reduce the production of Aβ from the beginning and thus become a new and effective treatment for AD. Schisandra glaucescens mainly distributes in the western of Hubei province and south-eastern of Sichuan province. Its stems were traditionally used for the treatment of insomnia and spontaneous sweating and the fruits for rheumatism and arthritis, etc. Our previous studies revealed that the extracts and some

英文关键词： Schisandra glaucescens；Schisandra；Alzheimer’s disease；Neuroprotective；Lignans