基于原电池原理释药的聚吡咯药物芯片的制备与性能研究

项目名称： 基于原电池原理释药的聚吡咯药物芯片的制备与性能研究

项目编号： No.31070845

项目类型： 面上项目

立项/批准年度： 2011

项目学科： 金属学与金属工艺

项目作者： 葛东涛

作者单位： 厦门大学

项目金额： 8万元

中文摘要： 本项目基于原电池原理，利用微机电（MEMS）技术，成功构建出一种微型的，无需外加电源便可释放药物，且具有一定控制能力的聚吡咯药物释放系统。重点研究了药物释放芯片的设计和构建手段，成功制备出易于批量制备的原电池聚吡咯药物释放芯片；同时考察了相关因素对药物芯片稳定性和储药性能的影响，确定了最佳储药的电化学条件；考察了在不同分子量高分子保护下药物芯片的释放情况，如我们所预期，该方法对该释放系统有一定控制作用。本项目研究结果简化了药物芯片的药物释放程序，降低药物芯片的制备和运行成本，方便了药物的储存运输，增强芯片对药物释放过程的控制能力，推动药物芯片向多样化、实用化发展，为人类带来一种更加方便有效并极具产业化前景的新型药物释放系统。

中文关键词： 药物芯片；聚吡咯；原电池；药物释放

英文摘要： In this project，a micro self-powered polypyrrole(PPy)-based drug release system was developed based on MEMS technology.The system based on the galvanic cell mechanism is controllable by using different type of biodegradable polymers.We focused on the design and constructing means of the microchip,and successfully built the batch processing drug released PPy-microchip. At the same time, the related factors affecting the stablity and the drug loading was investigated. We found the best electrochemistry condition of the drug loading/raleasing protected by different type of polymers.As we thought before,this method is controllable for this releasing system. The project simplify the drug releasing process, decrease the production cost, as well as facilitate the store and the transport of the microchip. It is excepted that the results of the project will be great useful for the development of an novel drug release system with significant potential for in vivo applications.

英文关键词： microchip;polypyrrole;galvanic cell;drug delivery