生物相容性嵌段共聚物与无机磁光纳米粒子的组装与过程调控

项目名称： 生物相容性嵌段共聚物与无机磁光纳米粒子的组装与过程调控

项目编号： No.21274145

项目类型： 面上项目

立项/批准年度： 2013

项目学科： 数理科学和化学

项目作者： 姬相玲

作者单位： 中国科学院长春应用化学研究所

项目金额： 82万元

中文摘要： 实现对多种基元自组装过程的调控以及揭示组装基元间相互作用的本质和协同规律，是当前自组装研究的难点和发展的突破点。本项目拟设计和制备带有机配体的功能性（磁性、荧光、磁光）单分散无机纳米粒子作为功能基元，生物相容性嵌段共聚物（中性、带电）自组装形成不同形貌的胶束作为结构基元，通过设计体系中多种力和多重相互作用（氢键作用、配位作用、静电作用、疏水作用等）的主导关系，利用功能性无机功能基元的监测作用及结构基元的导向作用，建立基元的结构和实验参数与组装体形态结构及性能之间的构效关系；同时采用计算机模拟方法研究不同条件下组装过程、预测组装体形态，将实验结果与理论模拟相结合，提出组装过程中的物理模型和组装机理，揭示弱相互作用的协同效应，以期得到多种结构可控的功能性有序组装体，并尝试将典型的1-2个有序组装体应用于免疫检测和药物释放跟踪领域。

中文关键词： 嵌段共聚物；无机纳米粒子；组装；非共价键相互作用；计算机模拟

英文摘要： Currently, self-assembly focuses on tenability of many kinds of building blocks during assembled procedure and indicating the essential interaction and synergetic effects. Here, we will design and prepare the monodispersed functional inorganic nanoparticles (magnetic, luminescent, magnetic-luminescent) as functional blocks, self-assembled micelles with different size and morphologies from biocompatible block copolymers (neutral or charged) as structure blocks. Utilizing some forces and interactions (hydrogen bonding, chelating, electrostatic force, hydrophobic interaction, etc) as directing agents, and functionally inorganic blocks as detect labels, we can establish the relationship between structure of building blocks and experimental parameters, particularly in correlation of morphologies of assembled aggregates and properties. Simultaneously, computer simulation is exploited to study the assembled procedure and to predict morphologies of assembled aggregates. Based on experimental results and theoretical simulation, the physical models and assembly mechanism are proposed. Definitely, it will imply some synergistic effects from weak interactions. We anticipate that many kinds of ordered assembled aggregates with controllable structures and functions are available. Finally, one or two typical ordered assembled

英文关键词： block copolymer；inorganic nanoparticle；assembly；non-covalent interaction；computer simulation