整复颈椎筋出槽骨错缝手法力学机制的三维有限元分析与研究

项目名称： 整复颈椎筋出槽骨错缝手法力学机制的三维有限元分析与研究

项目编号： No.81473702

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 医药、卫生

项目作者： 詹红生

作者单位： 上海中医药大学

项目金额： 74万元

中文摘要： 整复手法是治疗颈椎病的常见方法，其疗效及安全性已得到确证。基于颈椎筋出槽骨错缝是颈椎病发病的关键病机的认识，本课题采用虚拟三维仿真技术与临床平行观察相结合的方法，对颈椎筋出槽骨错缝生物力学基础和手法力学机制进行研究。首先，采集受试者真实测量数据，分别创建正常人与筋出槽骨错缝的颈椎有限元模型，观察模型动静态应力应变效应与血流动力学变化；其次，采用三维动态捕捉系统测量手法运动学与动力学参数，并仿真加载于上述模型，观察手法的力学效应；最后，参照临床治疗后患者的真实检测数据，调整同一受试者的原有模型参数，对比观察模型的生物力学状态。通过横向观察受试者的正常与病理模型，并纵向对比治疗前后的力学效应，进一步验证和完善颈椎筋出槽骨错缝的生物力学基础；同时，通过仿真手法加载，揭示整复手法治疗颈椎病的力学作用机制。

中文关键词： 颈椎病；中医整复手法；筋出槽骨错缝；有限元模型；流固耦合

英文摘要： The manual rectification of TCM is a common approach for the treatment of cervical spondylosis and related diseases, which has been identified for its efficacy and safety. Based cervical Jin Chu Cao and Gu Cuo Feng is the key pathogenesis of cervical diseases, we would apply a combination of methods for observation of virtual three-dimensional simulation technology in parallel with the follow-up clinical diagnosis and treatment, which aimed to study the biomechanical mechanisms of Cervical Jin Chu Cao and Gu Cuo Feng and the manual rectification of TCM. Firstly, the real data of the subjects were measured respectively, for buliding a normal and Jin Chu Cao and Gu Cuo Feng FEMs of the cervical spine, then we would observe the static and dynamic effects and hemodynamic changes on the model; Secondly , we would simulate the manual rectification of TCM on these FEMs, which the three-dimensional motion capture system would be used for the mechanical parameter measurement, for observation of the effects on the models. Finally , according the real test data of the subjects after treatments, the parameters of the original FEMs would be adjusted, then record the state of stress and strain and hemodynamic changes on new models again. This program would like to verify cervical Jin Chu Cao and Gu Cuo Feng biomechanics through the lateral observation between the normal model and the pathological one, meanwhile the longitudinal comparison with the pathological model before and after treatment would be recorded as well. Moreover, through the simulation of the manual techniques loading, we hope to depth reveal the biomechanics of the manual rectification of TCM for cervical spondylosis.

英文关键词： Cervical spondylosis;the Manual Rectification of TCM;Jin Chu Cao and Gu Cuo Feng;Finite Element Model;Fluid- Structure Interaction