面向脑电信号的实时脑皮层功能连通性成像技术研究

项目名称： 面向脑电信号的实时脑皮层功能连通性成像技术研究

项目编号： No.61201054

项目类型： 青年科学基金项目

立项/批准年度： 2013

项目学科： 电子学与信息系统

项目作者： 栾峰

作者单位： 东北大学

项目金额： 25万元

中文摘要： 传统的脑功能成像技术只能用于研究孤立的神经活动信息。近来，关注于大脑不同区域连通性动态机理的研究持续增多，原因在于这类信息有助于更好地揭示脑皮层区域的功能网络，为脑皮层神经活动的理解提供更全面的信息。基于脑电的脑皮层神经成像技术近年来得到了广泛的发展，但目前的技术通常是针对于非实时的离线分析，既没有对脑皮层神经活动进行实时的在线监测，也没有从实时性要求的角度去分析、设计神经连通性成像算法和系统。本项目旨在开发一个实时脑皮层（而不是颅骨之外的头皮层）功能连通性成像系统，此系统能够在神经源层面上实时检测并追踪脑皮层表面不同感兴趣区连通性的时空演变，同时，此系统的实现将在脑机接口、脑电生物反馈、实时诊断脑部疾病等多个领域有着广阔的应用前景。

中文关键词： 神经成像；功能连通性；基于区域的方法；噪声抑制；多模框架

英文摘要： Traditional studies of neuroimaging have been proposed to reconstruct the activities and study such activity-specific changes in isolation, however, this isolated study is insufficient. Recent studies on bio-electromagnetic problems have shown that a satisfactory understanding of underlying mechanisms requires performing cortical connectivity analysis. Although neuroimaging techniques are constantly being improved and different methods have been comprehensively studied, most studies mainly focus on localization bias or spatial resolution instead of fully investigating unique real-time cortical functional connectivity imaging characteristics. Thus, a complete and rigorous study of the performance of inverse techniques for real-time cortical functional connectivity imaging is placing increasing demands. This project focuses on EEG-based real-time cortical functional connectivity techniques for monitoring and tracing dynamic changes in cortical functional connectivity between different regions of interest on a subject's cortical surface, not on the subject's scalp surface. This project extends the work of current neuroimaging techniques in two important ways. It investigates both a neuroimaging inverse method for cortical functional connectivity, using a distributed source model, and a system that shows the advanta

英文关键词： Neuroimaging；Functional connectivity；Region-based approach；Noise suppression；Multimodal framework