超临界二氧化碳中温敏型分子印迹聚合物微球的合成及其性能研究

项目名称： 超临界二氧化碳中温敏型分子印迹聚合物微球的合成及其性能研究

项目编号： No.50863004

项目类型： 地区科学基金项目

立项/批准年度： 2009

项目学科： 化学工业

项目作者： 曹丽琴

作者单位： 新疆大学

项目金额： 25万元

中文摘要： 以scCO2为绿色反应介质，采用非共价印迹方法，分别以4-乙烯基吡啶、N-异丙基丙烯酰胺为功能单体，乙二醇二甲基丙烯酸酯为交联剂，以(S)-萘普生、尿嘧啶、金属离子Cu(Ⅱ为模板，构筑热敏型印迹聚合物(MIP)。通过吸附振荡结合紫外光谱、原子吸收、FTIR、SEM、XRD等测试方法研究MIP 微球对于 (S)-萘普生、尿嘧啶、Cu(Ⅱ等模板分子选择性识别特性；结果表明：(S)-萘普生分子印迹聚合物对模板分子的高、低平衡离解常数分别为：Kd1 =0.50 mmol L-1，Kd2 = 5.3 mmol L-1，Qmax1 = 25.5 μl g-1，Qmax2 = 82.2 μl g-1。热敏型Cu(Ⅱ-MIIP对铜离子的吸附容量为 21.25 mgog-1，其选择性顺序为 Cu(Ⅱ>Zn(Ⅱ>Co(Ⅱ，最大选择性吸附系数达2.13。双功能单体温敏型Cu(Ⅱ-MIIP在相转变温度之前、pH 为 7.0 左右，对Cu(II)的吸附量较高，Cu2+/Zn2+, Cu2+/Ni2+ 及Cu2+/Co2+ 的选择性因子分别是 1.41，7.40 和 6.48。

中文关键词： 超临界流体；分子印迹聚合物；温度敏感；绿色合成

英文摘要： The subject is intended to prepare temperature-sensitive molecular imprinted polymers (MIPs) microspheres using scCO2 as reactive media and non-covalent imprinting method. Proven the structure of MIPs microspheres with the imprinted efficiency and the absorption capacity of the molecular template, as well as MIPs response to environmental stimulation and its control. Through the Vibration absorption combination of UV detection and atomic absorption spectroscopy, fourier transform infrared, thermo-gravimetric analysis, and X-ray diffraction techniques. To study selective identifying characteristics of MIP microspheres for uracil, (S)-naproxen, Cu(II) ions. And thus have access to such sensitive MIP microspheres design and principle of preparation. The project is to develop simple, security, economized, green method of the preparation of molecularly imprinted polymer microspheres, the results of their research can provide a scientific basis for the green synthesis of the new imprinted materials of environment-responsive. Compared with the nonimprinted polymers (NIPs), the MIPs displayed much higher (S)-naproxen uptake in acetonitrile. Scatchard analysis shows that two classes of binding sites were formed in the MIPs in the concentrations range studied. The calculated dissociation constant Kd1 and the apparent maximum binding capacities Qmax1 for the high affinity sites are 0.50 mmol L-1 and 25.5 μl g-1, while Kd2 and Qmax2 for the low affinity sites are 5.3 mmol L-1 and 82.2 μl g-1, respectively. The temperature-sensitive Cu(II) ion imprinted polymer show the following metal ion affinity order：Cu(II)>Zn(II)>Co(II)，the adsorption capacity of the Cu(II)-imprinted polymers was 21.25 mgog-1, and it was found to have an imprinting ef?ciency of 2.13 for Zn and Co ions. With addition of small amount of methanol as coselvent, using copper ion as model template, MAA and NIPA as funcional monomer, the adsorption capacity of the Cu(II)-MIIP for Cu(II) ions was studied in different conditions(pH、temperature) and selectivity adsorption for different metal ions. The results were shown that the imprinted polymers had excellent selectivity for Cu(II) ions.

英文关键词： Supercritical fluids;Molecularly imprinted polymers;Temperature-sensitive;Green synthesis