基于超小磁性纳米颗粒的多模态分子影像探针

项目名称： 基于超小磁性纳米颗粒的多模态分子影像探针

项目编号： No.81471657

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 医药、卫生

项目作者： 李桢

作者单位： 苏州大学

项目金额： 72万元

中文摘要： 肿瘤仍是人类健康的主要杀手之一，早诊断和早治疗是降低肿瘤死亡率的关键。联合使用多种优势互补的影像技术可以大大提高早期肿瘤的诊断准确率。本项目将以乳腺癌的早期诊断和治疗为导向，发展基于磁性氧化铁纳米颗粒，铜硫族纳米颗粒和同位素64Cu的多功能探针。该探针可以同时用于核磁共振成像、光声成像、正电子发射断层扫描、和光热治疗。高质量磁性纳米颗粒将采用高温分解法和高温共沉淀法制备，优化合成条件使其核磁共振成像性能最大化以获取乳腺癌肿瘤微环境相关信息。铜硫族纳米颗粒将在室温下制备使其光热转化效率最高，以便通过光声成像使肿瘤新生血管可视化和采用光热效应对肿瘤治疗。基于同位素的正电子发射断层扫描将用于体内追踪和定量分析探针。本课题的研究成果有望为乳腺癌和其它实体肿瘤的早期诊断和治疗带来新突破。

中文关键词： 磁性氧化铁；超小纳米颗粒；多模态成像；核磁共振成像；光声成像

英文摘要： Cancer remains a leading cause of death, and detection and treatment of cancer at an early stage is the key to decreasing mortality. The complementary use of multi modal imaging technologies can significantly improve the detection accuracy. This project aims to develop multimodal imaging probes based on magnetic iron oxide nanoparticles, copper chalcogenide nanoparticles, and copper isotopes。The resultant multimodal probes can simultaneously serve as agents of magnetic resonance imaging (MRI), photoacoustic imaging (PA), positron electron tomography (PET), and photothermal therapy (PTT) for detection and treatment of early breast cancer. High-quality magnetic iron oxide nanoparticles will be prepared by high-temperature decomposition method and high-temperature coprecipitation approach to exhibit the maximal performance of MRI for accurate acquire microenvironment information in breast cancer. Copper chalcogenide nanoparticles will be synthesized at room temperature, and optimized to exhibit high photothermal conversion efficiency for visualization of newly formed tumor-associated vessels through PA, and the treatment of cancer by PTT. Highly sensitive PET will be used to track probes in-vivo and quantify their biodistribution. The outcome of this project would bring breakthrough for early detection and treatment of breast cancer and other solid tumors.

英文关键词： magnetic iron oxide;ultrasmall nanoparticles;multimodal imaging;magnetic resonance imaging;photoacoustic imaging