基于系统生物学的原发性肝癌与大肠癌“异病同证”和“异病同治”的研究

项目名称： 基于系统生物学的原发性肝癌与大肠癌“异病同证”和“异病同治”的研究

项目编号： No.81330084

项目类型： 重点项目

立项/批准年度： 2014

项目学科： 医药、卫生

项目作者： 苏式兵

作者单位： 上海中医药大学

项目金额： 290万元

中文摘要： 证候是中医对疾病认识、临床诊疗和疗效评价的核心基础。“异病同证”和“异病同治”是中医辨证施治的特点之一。本课题从“病证结合”研究出发, 运用系统生物学原理和方法，通过采集原发性肝癌（简称肝癌）与大肠癌患者证候信息，检测患者临床指标和基因组、蛋白组和代谢物组的变化，分析中医证候信息和生物信息的关联，揭示其生物物质特征及“异病同证”的分子机制；制订并实施中医治疗肝癌与大肠癌的辨证施治方案，从患者的证候积分、临床和系统生物学指标、生存质量和生存率等，评价中医辨证治疗肝癌与大肠癌的疗效，探讨其“异病同治”的作用机制。

中文关键词： 原发性肝癌;大肠癌;异病同证;异病同治;系统生物学

英文摘要： Traditional Chinese medicine (TCM) syndromes is a core foundation of .disease knowledge, clinical diagnosis and treatment and curative effect evaluation in TCM. “Same TCM Syndrome for Different Diseases” and “Same Treatment for Different Diseases” is one of the characteristics of TCM syndrome differentiation and treatment. .This study is the “disease-TCM syndrome combination” research baced on principles and methods of stems biology, which is (1) through acquisition of primary hepatocellular carcinoma (HCC) and colorectal cancer patients with TCM syndrome information, detection of clinical indicators and genomic, proteomic, and metabolites changes, analyzing the correlation between TCM syndromes and biological information, and revealing its biological material characteristics and the molecular mechanisms of “Same TCM Syndrome for Different Diseases”; (2) Developing and implementing the program of TCM syndrome differentiation and treatment for HCC and colorectal cancer to evaluate the efficacy of TCM syndrome based-treatment of HCC and colorectal cancer with TCM syndrom scores, clinical and systems biological indicators, quality of life and survival rate, and to revealing the mechanism of the “Same Treatment for Different Diseases”.

英文关键词： primary hepatocellular carcino;colorectal cancer;Same TCM Syndrome for Differen;Same Treatment for Different D;systems biology