面向糖尿病酮症酸中毒诊断的CeO2基混成电位型丙酮气体传感器的研究

项目名称： 面向糖尿病酮症酸中毒诊断的CeO2基混成电位型丙酮气体传感器的研究

项目编号： No.61473132

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 自动化技术、计算机技术

项目作者： 梁喜双

作者单位： 吉林大学

项目金额： 86万元

中文摘要： 通过便携式检测仪测量呼气中的丙酮浓度，可以对糖尿病患者的酮症酸中毒病况进行无创伤诊断和实时监控，在临床医学和在宅监护上具有重要意义。研制高灵敏、高选择和高抗湿的丙酮传感器是开发低成本和小型化丙酮检测仪的基础和关键。本项目基于混成电位感知机理，利用CeO2固体电解质和金属氧化物电极构建全固态丙酮传感器。通过掺杂和烧结技术的优化来提高CeO2固体电解质的电导率、密度、机械强度和厚膜质量，为构建丙酮传感器奠定材料基础；通过氧化物敏感电极材料的组成优化和多孔化设计以及高性能多孔纳米三相反应界面的构筑（两级增感策略），提高传感器的灵敏度和选择性，使检测下限达到100ppb；设计气体传感器和湿度传感器的平面阵列结构，利用石墨烯/氧化物湿敏元件对丙酮传感器进行高精度湿度补偿，以提高抗湿性。通过系统的创新性研究，使混成电位型丙酮传感器满足酮症酸中毒诊断要求，同时希望在新型感知机制探索方面取得新突破。

中文关键词： 丙酮传感器；糖尿病酮症酸中毒；CeO2；混成电位；湿度补偿

英文摘要： By detecting the concentration of the acetone with the portable detector, the ketoacidosis could be non-invasively diagnosed and real-time monitored for people with diabetes, which is of great significance for clinical medicine and home caring. There is no doubt that developing the acetone sensor with high sensitivity, great selectivity and excellent moisture resistance is the key and the basis to develop the low-cost and smart acetone detector. On a basis of the mixed-potential mechanism, the project is focused on the fabrication of solid-state acetone sensor using metal oxide as electrode and CeO2 as electrolyte. Specifically, by optimizing parameters of doping and sintering, the conductivity, density, mechanical strength and the thick-film quality could be improved, which could provide excellent electrolyte for the sensor; By optimizing the composition of the metal oxide of the electrode material, fabricating the porous electrode, and constructing porous nanoscale three-phase with high performance (the two-level enhancement tactic), the sensitivity and the selectivity are improved significantly, with the lower limit for detection falling to 100ppb; By constructing planar array with gas sensor and humidity sensor, and by compensating the humidity for the acetone sensor with the grapheme /oxide humidity sensing element, the moisture resistance of the sensor is enhanced significantly. Taking advantage of the innovative research in a systematic way, the mixed-potential acetone sensor could meet the requirements of the diagnosing of the ketoacidosis, and at the same time, more breakthrough of the sensing mechanism is also expected.

英文关键词： acetone sensor;diabetes ketoacidosis;CeO2;mixed potential;humidity compensation