热疗过程中皮肤组织的热力行为与温度调控机制

项目名称： 热疗过程中皮肤组织的热力行为与温度调控机制

项目编号： No.51506151

项目类型： 青年科学基金项目

立项/批准年度： 2016

项目学科： 能源与动力工程

项目作者： 王雅博

作者单位： 天津商业大学

项目金额： 20万元

中文摘要： 热疗过程中组织的温升与热损伤均会引起血管形态的变化以及血液灌注的改变。大的血液灌注会从加热部位带走更多的热量，从而加速热量在组织内的分散；较小的血液灌注则有助于热量的沉积，容易导致组织的热损伤。理解血液灌注率变化机制及温变所诱发的生物力学行为，对提高热疗中“热量”确定和温度场估计的准确性有着重要意义。本项目将研究在体皮肤组织血管形态的动态变形特征，探究不均匀温度场引起的皮肤组织热应力及血管变形行为；将毛细血管及其周围组织视为弹性多孔体，分析皮肤组织孔隙结构的变化，研究在热刺激过程中，综合考虑血管微结构，血液流动等影响规律的生物力学行为与温度变化的耦合关系。研究结果为揭示热疗过程中皮肤的温度调节机制提供理论支持。

中文关键词： 皮肤组织；热疗；温度分布；血液灌注率；生物力学

英文摘要： Both the rise of temperature and the thermal damage may cause the change of vascular morphology and blood perfusion during thermal therapy. Higher blood perfusion takes more heat away from the heated location hence accelerate the distribution of heat in tissue. Lower blood perfusion conduces to the deposition of heat in tissue and causes the thermal damage easily. Understanding the change mechanism of blood perfusion and biological mechanical behavior induced by temperature plays an important role in correctly evaluating the “quantity of heat” and temperature distribution. This project will study the dynamic behavior of in vivo vascular morphology in skin and develop the thermal stress and vascular morphology change under uneven temperature field. The capillaries and surrounding tissues are treated as pore-elastic media. The structure variation of pore structure of the skin is analyzed and the coupling relationship between temperature and biomechanical behavior considering the vascular micro structure and blood flow is studied. The research results help to reveal thermoregulation mechanism of skin.

英文关键词： skin tissue;hyperthermia;temperature distribution;blood perfusion rate ;biomechanics