微观孔隙结构对人工软骨的力学和生物学性能的影响

项目名称： 微观孔隙结构对人工软骨的力学和生物学性能的影响

项目编号： No.81501860

项目类型： 青年科学基金项目

立项/批准年度： 2016

项目学科： 医药、卫生

项目作者： 谢杰

作者单位： 中南大学

项目金额： 18万元

中文摘要： 纳米羟基磷灰石-聚乙烯醇水凝胶是一种具有良好前景的人工软骨材料，但存在难以和周围组织整合问题。我们的前期研究发现软骨细胞能在人工软骨的周围良好的增殖，但难以深入其中，究其原因主要为材料的微观孔隙结构达不到要求。同时我们前期研究将纳米羟基磷灰石-聚乙烯醇水凝胶沉积于一种3D打印的醇溶型的有机高分子支架上，利用前者不溶的乙醇的特性将支架去除，从而可以制备出一种具有联通孔且孔隙率和微观孔隙结构可控的新型人工软骨。本研究拟制备出一系列具有不同微观孔隙结构的人工软骨，通过比较各组的生物力学、摩擦学等物理性能以及软骨细胞在人工软骨上的生物学行为，探讨微观孔隙结构对人工软骨物理学和生物学性能的影响，从而确定人工软骨最佳的微观孔隙结构，为解决人工软骨难以和周围组织整合问题的科学问题提供一种新的方法。

中文关键词： 微观孔隙结构；人工软骨；增材制造；软骨修复；3d打印

英文摘要： Nano-hydroxyapatite- poly (vinyl alcohol) hydrogel is a kind of artificial cartilage materials which have good prospects , but it is pretty hard to integrate with surrounding tissues. Our previous studies have found that cartilage cells can proliferate around the artificial cartilage, but it is very difficult to grow deeply in them, the main reason is that the micro-pore structure of materials can not meet the requirements. Then we deposited nano hydroxyapatite - poly (vinyl alcohol) hydrogel in a alcohol soluble organic polymer scaffold which is produced by 3D-printing in our previous studies,a new type of artificial cartilage having unicom holes, the porosity and microstructure of which is controlled,can be produced in consideration of nano hydroxyapatite - poly (vinyl alcohol) hydrogel`s insolubility in alcohol. In our study, a series of artificial cartilage with different micro-pore structure are prepared.Through comparing biomechanics，tribology and biological performance in different groups,the effect of micro-pore structure on physics and biology of artificial cartilage can be explored to determine the best microscopic pore structure. Consequently an outstanding new method is provided to solve the problem of the integration artificial cartilage with surrounding tissues.

英文关键词： micro-pore structure;artificial cartilage;additive Manufacturing;cartilage repair;3d printing