项目名称: 刺激响应无机/有机聚电解质原位矿化纳米凝胶载胰岛素口服传输性能研究
项目编号: No.51202221
项目类型: 青年科学基金项目
立项/批准年度: 2013
项目学科: 无机非金属材料学科
项目作者: 黄霞
作者单位: 郑州大学
项目金额: 27万元
中文摘要: 载蛋白质体系口服给药疗效好成本低,但对载体材料要求苛刻。本项目拟采用温和简单的自组装法与插层聚合法,合成以壳聚糖为壳层,两亲丙烯酸/纳米粘土两亲插层网络为核层的刺激响应载胰岛素纳米凝胶,并进行相关模拟口服传输实验。凝胶制备过程自组装、载药、原位矿化同步完成;内层网络结构可将胰岛素药物纳米化并局限在每个网格中,形成类"向日葵"结构,使药物实现纳米尺度的网格化均布,提高封装率的同时保证了均匀释放;矿化过程的静电推斥作用形成空腔"缓冲带",还起到了矿化交联效果,在超分子体系内构成内嵌的网状结构。通过这一结构设计解决蛋白质载体封装与突释无法统一的瓶颈问题。本项目旨在通过对以上体系探索载体结构对降解、释药性能及蛋白质活性的影响,考察降解过程中载体微观结构变化与性能变化的相关性,建立载体降解与释药间的量化模型,完善口服传输的相关理论。
中文关键词: 药物载体;有机/无机杂化;水凝胶;取向/排列;功能化的组织工程支架
英文摘要: A novel Stimuli-Responsive insulin oral delivey system consisted of an amphiphilic Nanocomposite Gel nuclear layer by intercalation polymerization and modified chitosan shell will be prepared by self assembled, Oral delivery experiment were prepared in vitro.Self-assembly, drug loading,and the in situ mineralization is complete at the same time.Inner network structure devided insulin drug in nano scale and assigned insulin drop in each grid ,form a class of "Sunflower"like structure ,in which drug to achieve nanometer scale bulk disperse. The electrostatic repulsion effect of mineralization formed the cavity with embedded network structure in supermolecular. We want to estabilshed structure-property correlation by study the effect of the carrier structure on the degradation and drug release property . Studying the carrier microstructure change and performance change during the degradation process, the establishment of the quantitative model of the carrier degradation and drug release, perfect theories of oral delivery.
英文关键词: Drug carriers;Organic/Inorganic hybrid;hydrogel;ordered/arrangement;Functional TE