钛材表面pH响应性抗菌涂层的构筑及生物学评价

项目名称： 钛材表面pH响应性抗菌涂层的构筑及生物学评价

项目编号： No.51303218

项目类型： 青年科学基金项目

立项/批准年度： 2014

项目学科： 一般工业技术

项目作者： 刘鹏

作者单位： 重庆大学

项目金额： 26万元

中文摘要： 通过表面修饰赋予钛及钛合金材料抗菌性能，对于解决其临床术后感染问题具有重要意义。本项目旨在结合层层自组装、电化学阳极氧化和药物释放技术，针对细菌感染的弱酸性环境，展开钛材表面新型pH响应性抗菌涂层的研究。通过电化学阳极氧化在钛材表面制备二氧化钛纳米管阵列，作为抗菌药物的存储器；进而利用层层自组装技术在二氧化钛纳米管表面构筑pH响应性聚电解质多层膜，作为抗菌药物的封堵层；在细菌感染的弱酸性环境下，多层膜发生解组装，实现纳米管中药物的可控释放；从而在钛材表面逐步建立起一个能够对pH刺激进行智能响应的抗菌涂层。系统研究层层自组装制备pH响应性多层膜的有效性，探寻抗菌药物的释放机制，评价该功能涂层的体外抗菌性和细胞相容性。本课题将为钛基植入材料表面抗菌设计提供新思路，促进其在组织修复与再生领域的应用。

中文关键词： 钛基材料；层层自组装；表面修饰；pH响应；抗菌

英文摘要： In order to solve the currently existed postoperative infection, it is great significance to make titanium and its alloys with antibacterial function via surface modification. This project is aimed at developing a pH-responsive antibacterial coating on the surface of titanium substrate, concerning the weakly acidic environment in case of bacterial infection. The fabrication approach combines the techniques of layer-by-layer (LBL) self-assembly and electrochemical anodization with sustained release of drugs. Titania nanotube arrays as reservoirs for antibacterial drug are constructed on titanium substrate via electrochemical anodization method. pH-responsive polyelectrolyte multilayer films are fabricated on the surface of titania nanotube for sealing antibacterial drug via LBL self-assembly. The lightly acidic environment occurring in case of bacterial infection leads to a disassembly of multilayer film, which consequently induces controlled release of antibacterial drug from nanotube. Thus, a pH-responsive antibacterial coating is gradually constructed on the surface of titanium substrate. The effectiveness of pH-responsive polyelectrolyte multilayer films via LBL self-assembly is systematically investigated. The release mechanism of antibacterial drug is explored. Antibacterial property and biocompatibility of

英文关键词： Titanium-based materials；Layer-by-layer self-assembly；Surface modification；pH-responsive；Antibacterial