基于隧道磁电阻的蛋白质芯片磁生物传感器系统研究

项目名称： 基于隧道磁电阻的蛋白质芯片磁生物传感器系统研究

项目编号： No.61501453

项目类型： 青年科学基金项目

立项/批准年度： 2016

项目学科： 无线电电子学、电信技术

项目作者： 来强涛

作者单位： 中国科学院微电子研究所

项目金额： 21万元

中文摘要： 蛋白质芯片在疾病相关蛋白的发现和诊断以及新药研发领域具有无可比拟的优越性，具有巨大的社会需求和广阔的市场前景。基于隧道磁电阻的蛋白质芯片磁传感器系统具有高灵敏度、高通量、快速、廉价等特点，有望成为未来蛋白质芯片检测的主流技术。本项目将对基于隧道磁电阻的蛋白质芯片磁传感器系统中的基础科学问题和技术问题进行系统研究。探究提高隧道磁电阻的检测灵敏度的工艺改进方法，研究磁传感器微弱低频信号的快速、高保真检测方法。力争实现蛋白质芯片，隧道磁电阻传感器阵列和外围信号处理IC的系统级封装。目标传感器系统的蛋白质检测浓度可低至20f mol/L，同时检测16路信号，检测周期小于30分钟。输入参考噪声小于1nT/sqrt(Hz) ，检测磁场强度0.01-200 Oe。系统整体功耗小于8mW(VDD-3.3V )。发表SCI/EI论文2-3篇,发明专利2篇

中文关键词： 磁电传感器；隧道磁电阻；蛋白质芯片；磁生物传感器；系统级封装

英文摘要： The protein chips have incomparable advantage of protein bio-molecular detection and new medicine research and development. The market demand of protein chip is huge. The multi-analytic ability, high sensitivity, quick and inexpensive of protein chip magneto-resistive biosensor based on tunnel magneto-resistive (TMR) make it a strong contender for versatile and portable molecular diagnostics in both research and clinical settings. This project aims at developing TMR based protein assay magneto-resistive biosensor array system. In order to develop magneto-resistive biosensor with high performance, we will focus on the following investigations. Firstly, systematic study will be done to explore the new process technology for develop high magneto-resistive ratio and detection sensitivity. Secondly, the distortion mechanism for small low frequency signal of the TMR biosensor will be investigated and the periphery signal process IC.is designed for quick and undistorted detection of biosensor. Finally, the system in package of TMR array, protein chip and periphery signal process IC will be realized which has high sensitivity (<20f mol/l), high throughput (16 channel), rapid detection (<30 minutes) characteristics. The input reference noise is less than 1nT/ sqrt(Hz), dynamic range is 0.01-200 Oe. The power consumption is less than 8mW from a 3.3 V supply. After carrying out this project, the following achievements will be brought forth: 2-3 publications in SCI/EI journals, 2 patents.

英文关键词： Magnetoelectric sensor;Tunneling Magnetoresistance;Protein Chip;Magnetic Biosensor;System in Package