多肽叶绿素衍生物在生理条件下的自组装和光声成像研究

项目名称： 多肽叶绿素衍生物在生理条件下的自组装和光声成像研究

项目编号： No.21502035

项目类型： 青年科学基金项目

立项/批准年度： 2016

项目学科： 数理科学和化学

项目作者： 周进

作者单位： 国家纳米科学中心

项目金额： 21万元

中文摘要： 超分子组装在药物载体和生物成像领域有着广泛的应用，近年来新兴的光声成像领域也不例外。超分子组装体和小分子作为光声成像的造影剂有各自的不足，从而限制其应用前景。在生理条件下原位构筑超分子组装体的方法可以兼具小分子和超分子造影剂的特点。但是，目前在生理条件下的自组装研究的并不多。本项目利用固相多肽合成技术合成一系列不同氨基酸组成的多肽叶绿素衍生物，研究其在生理条件下的聚集行为和光学性能，考察不同化学结构对超分子自组装的影响。进一步通过研究超分子组装与光声性能的关系，建立分子结构与光声性能之间的关系，为设计高效光声成像造影剂奠定理论基础，为发展新的多功能的光声成像方法提供新思路和新途径。

中文关键词： 叶绿素；卟啉；自组装；超分子；光声成像

英文摘要： Supramolecular assembly has been widely used in drug delivery and bio-imaging fields. In recent years, supramolecular assembly also used in the emerging field of photoacoustic imaging. Supramolecular assembly and small molecules as photoacoustic contrast agents have their own disadvantages, which limits its application. The method of building a supramolecular assembly in situ under physiological conditions can combine the characteristics of small molecular and supramolecular contrast agents. However, there are not many studies about self-assembly under physiological conditions. This project uses solid phase peptide synthesis technique to synthesize a series of peptides chlorophyll derivatives. And we study their aggregation behavior and optical properties under physiological conditions. Then we examine the relationship between chemical structures and supramolecular self-assembly. Further by studying the relationship between supramolecular assembly and photoacoustic performance, we build the corelation of molecular structure and photoacoustic signal. This research can provide the theoretical basis for designing of high efficient photoacoustic contrast agent. Moreover, this result provide new ideas and ways for the development of multi-functional new photoacoustic imaging method.

英文关键词： Chlorophyll;porphyrin;assembly;Supramolecular;photoacoustic imaging