可点击树型共聚物的分子设计及其复合功能纳米载体的肿瘤靶向性能研究

项目名称： 可点击树型共聚物的分子设计及其复合功能纳米载体的肿瘤靶向性能研究

项目编号： No.51203116

项目类型： 青年科学基金项目

立项/批准年度： 2013

项目学科： 有机高分子材料学科

项目作者： 王亮

作者单位： 天津理工大学

项目金额： 25万元

中文摘要： 本课题针对肿瘤靶向给药的难题，通过可控活性聚合、点击化学等方法，设计合成一系列结构新颖的可点击树型聚酯/超支化聚缩水甘油醚两亲性嵌段共聚物。该共聚物不仅完全保留了聚酯、聚醚类材料所固有的良好生物相容性、可降解排除、长循环等优势，而且其亲水链段的超支化结构将提供较线性结构更多的可修饰端基，更长的体内循环时间。利用其可点击端基更可进一步实现在点击化学温和高效的条件下进行靶向分子的偶联，从而最大限度的保持偶联后靶向分子的生物活性。研究树型共聚物的可控合成方法；研究载体表面靶向分子密度及空间自由度对其靶向性能的影响，探寻其影响规律；研究树型共聚物分子组成对其载体结构及载药能力的影响规律。借助树型共聚物的结构特点和性能优势，构建集靶向给药、磁响应和荧光可视功能为一体的复合功能纳米载体，以实现对体内靶向过程的实时监控和定量检测。筛选适合靶向给药的纳米载体，通过动物实验评价其生物相容性和抑瘤效果。

中文关键词： 磁性纳米粒子；核磁成像；聚缩水甘油；苝二酰亚胺；石墨烯

英文摘要： In this project, focused on the problems related to cancer targeting drug delivery, a series of novel tree-like amphiphilic polyester/hyperbranched polyglycerol diblock copolymer with tunable properties and clickable extremities will be designed and synthesized via living polymerization and 'click' chemistry. These copolymers not only possess preferred properties derived from polyester and polyether such as biocompatibility, biodegradable and long circulation time, but also allow the coupling reaction between drug carrier and targeting molecules take place in a mild and effective condition. Thus, the biological activity of the targeting molecules can be maximally reserved after the coupling process. As for these tree-like copolymers and their drug carriers, studies will be pursued mainly from three aspects. Firstly, the synthetic method will be studied to obtain the tree-like copolymers with designable and controllable structure. Secondly, the targeting abilities of these nano-carriers formed from the tree-like copolymers will be examined via varying the surface densities and steric hindrance of the targeting molecules. Thirdly, the morphology and the encapsulation efficiency of the nano-carriers will be studied by tuning the component of the tree-like copolymers. To achieve real-time monitor and quantitative de

英文关键词： magnetic nanoparticles；MRI；polyglycidol；PBI；graphene