单胺氧化酶A基因多态性调节品行障碍神经网络特征的研究

项目名称： 单胺氧化酶A基因多态性调节品行障碍神经网络特征的研究

项目编号： No.81471384

项目类型： 面上项目

立项/批准年度： 2015

项目学科： 医药、卫生

项目作者： 姚树桥

作者单位： 中南大学

项目金额： 80万元

中文摘要： 品行障碍是青少年最常见的冲动控制障碍，其发病过程与单胺氧化酶A（MAOA）基因多态性有关，但MAOA基因在品行障碍中作用的神经机制尚不明了。本研究将通过整合行为学、分子遗传学及认知神经科学等学科研究方法，以低活性MAOA基因型（MAOA-L）和高活性MAOA基因型（MAOA-H）男性品行障碍患者及相应男性健康青少年对照为研究对象，采集各基因型组的行为学数据（品行障碍诊断访谈、攻击与反社会行为特征、冲动控制和神经心理等）、fMRI多模态数据（含冲动控制任务和静息态fMRI数据）及ERPs数据，运用最新的脑成像数据全脑神经网络连接分析方法和脑成像遗传学数据分析方法，对各基因型组全脑神经网络连接特征及MAOA多态性作用的脑神经环路或特征性神经核团激活模式进行深入分析，以揭示男性品行障碍患者的脑成像遗传学标记，为阐明品行障碍的神经病理机制，寻找客观诊断指标及制定防治途径提供新的实验证据。

中文关键词： 品行障碍；单胺氧化酶A基因多态性；攻击和反社会行为；功能磁共振成像；事件相关电位

英文摘要： Conduct disorder (CD) is the most common impulse control disorder in adolescents, with onset processes affected by the monoamine oxidase (MAOA) gene polymorphisms. However, how the MAOA gene plays its role in the neural mechanism of CD is still unknown. This study will integrate research methods of behavioral measurement, molecular genetics and cognitive neuroscience to evaluate the subjects, which are male conduct disorder patients with low-activity MAOA genotype (MAOA-L) and high-activity MAOA genotype (MAOA-H) as well as corresponding male adolescent healthy controls. Data from each genotypes and groups are collected, including behavioral data (diagnostic interview of CD, characteristics of aggression and antisocial behavior, impulse control and neural psychology, etc.), multimodal fMRI data (impulse control task fMRI and resting state fMRI data), and ERPs data. Using the latest neural imaging whole-brain network analysis and genetics brain imaging data analysis, we explore not only the characteristics of whole-brain network connections for different genotypes, but also the effects of MAOA polymorphisms on brain neural circuits or particular neural activation patterns. We aim to find the brain-imaging genetic markers for male patients with CD, and to elucidate the neural pathological mechanism of CD, in order to provide new experimental evidence for seeking objective diagnostic index, making prevention and treatment plans.

英文关键词： conduct disorder;MAOA polymorphism;aggressive and antisocial behavior;fMRI;ERPs