颈内静脉和椎静脉结构和血流动力学异常与颅内静脉窦血栓形成相关性研究

项目名称： 颈内静脉和椎静脉结构和血流动力学异常与颅内静脉窦血栓形成相关性研究

项目编号： No.81200912

项目类型： 青年科学基金项目

立项/批准年度： 2013

项目学科： 神经系统疾病、精神疾病

项目作者： 贾凌云

作者单位： 首都医科大学

项目金额： 23万元

中文摘要： 颅内静脉窦血栓（CVST）是一种好发于年轻人的脑血管病，并发症多，复发率和致死率高。目前仍有大约12.5%的CVST原因不明。静脉血流瘀滞是静脉血栓形成的三大要素之一。颈内静脉（IJV）和椎静脉（VV）是颅内静脉（窦）回流的主要通路，但是IJV和VV结构和血流动力学的异常与CVST发病的相关性缺乏大样本的研究。彩色多普勒超声（CDFI）能够同时评价血管二维结构和实时血流动力学变化。本研究欲通过CDFI对临床不明原因的CVST患者和正常对照组的IJV和VV结构和血流动力学参数进行对比分析；并将CVST患者分为IJV介入治疗组（介入治疗+常规治疗）和无介入治疗组（仅进行常规治疗），进行至少1年的血管超声随访和临床随访，探讨IJV和VV结构和血流动力学异常与CVST的相关性。本研究结果将为研究CVST发病原因和机制提供新的思路，为进一步有效治疗CVST，预防CVST复发，改善预后提供临床依据。

中文关键词： 颈内静脉；静脉窦血栓；结构；血流动力学；超声

英文摘要： Cerebral Venous Sinus Thrombosis (CVST) is a sepcial form of cerebrovascular disease with many complications and high risk of recurrence and dependency that usually affecting young individuals.So far, the causes of about 12.5% cases were unclear. Hemodynamic changes is one of the three essential factors for the development of thrombosis. Internal jugular vein (IJV) and vertebral vein (VV) are the main outflow pathways for the cerebral venous,however,there is no large sample study to illustrate the relationship of the morphological and hemodynamic abnormalities of IJV and VV with CVST. Color Doppler flow imaging (CDFI) can evaluate both vessel morphology and hemodynamics in real-time mode. In this study, by using CDFI, we would compare the morphology and hemodynamic parameters of IJV and VV　between normal healthy controls and CVST patients with unkown causes. Moreover,CVST patitents were categorized into two groups: only traditional treatment group and traditonal treatemnt with IJV intervention treatment group. All the CVST patients were followed up for at least 1 year in order to investigate the relationship of morphological and hemodynamic abnormalites of IJV and VV with CVST. This study would provide a novel idea for searching for the causes of CVST and provide clinic proofs for the treatment, prevention and

英文关键词： internal jugular vein；cerebral venous sinus thrombosis；morphology；hemodynamics；ultrasound