从胸部体表混合阻抗变化中分离出主动脉、肺部动脉和心室阻抗变化分量的研究

项目名称： 从胸部体表混合阻抗变化中分离出主动脉、肺部动脉和心室阻抗变化分量的研究

项目编号： No.61461033

项目类型： 地区科学基金项目

立项/批准年度： 2015

项目学科： 无线电电子学、电信技术

项目作者： 况明星

作者单位： 南昌理工学院

项目金额： 43万元

中文摘要： 目前心阻抗图一般用Kubicek法或Sramak法测量，并把它看作是主动脉容积变化引起的。但大量研究表明，这些方法测得的心阻抗图是由主动脉、肺部动脉和心室等容积变化共同产生的混合阻抗变化。用该方法得到的心功能结果既有左心的作用，又有右心的作用，用于评价左室心功能，缺乏正确的生理学基础，测量的可靠性较差，这是国际电生物阻抗研究领域内长期未解决的基础性问题。本课题设想，通过从胸部体表混合阻抗变化中分离出主动脉、左侧肺部动脉、右侧肺部动脉、左心室、右心室的阻抗变化分量来解决上述问题。研究内容是：胸部体表混合阻抗变化形成的机理，多导联检测胸部混合阻抗变化的方法，胸部阻抗方程组的建立，求解方程组得到上述各阻抗变化分量，并用动物实验验证，研制波形分离实验装置，测量和统计正常人和患者各分量的波形参数。本课题预期目标是：解决心阻抗图测量中长期存在的非唯一性问题，为心阻抗图的研究和应用奠定正确的理论基础。

中文关键词： 心阻抗图；混合阻抗变化；波形分离；胸部阻抗方程组；阻抗变化分量

英文摘要： Now the impedance carciography （ICG）is generally measured with Kubicek's method or Sramak's method, and suppose that the ICG is an impedance change, which evokes from the volume change of the aorta. But many studies have confirmed that the ICG measured by the these methods is kind of the mixed impedance change,which mainly evokes from the volume changes of the aorta, arteries in lungs and ventricles. Obviously, the cardiac function results obtained with this method include not only the left heart effects, but also include the right heart effects. This method lacks the correct physiological base for evaluating the cardiac function of left ventricle, and the measurement reliability is lower.This is a fundamental problem which is not solved in long time for the research field of the international electrical bio-impedance. This study try to solve the above problem through that the impedance change components for aorta, artery in left lung, artery in right lung, left ventricle and right ventricle are separated from the mixed impedance changes measured on the chest surface. Ite main reseach contents are that: the formatiom mechanism of the impedance change measured on the chest surface is investigated, the method that the thoracic mixed impedance changes are measured with more leads is seeked, thoracic impedance equations for separation are established,the above impedance change components are obtained through solving this equations,these compneonts are demonstrated with the animal expenriment, an expenriment equipment for the waveform separation is developed, the various impedance change components for the normal adults and patients are measued，and the waveform parameters of various components are calculated statistically. The expected aim of this study is that: the non-uniqueness problem in the measurement of the ICG is solved, the correct theoretical base is established for the reseach and applition of the ICG.

英文关键词： Impedance cardiography;Mixed impedance change;Waveform separation;Thoracic impedance equations;Impedance change component