钛合金表面纳米化、功能化和抗菌性能的研究

项目名称： 钛合金表面纳米化、功能化和抗菌性能的研究

项目编号： No.51201056

项目类型： 青年科学基金项目

立项/批准年度： 2013

项目学科： 金属材料学科

项目作者： 李宝娥

作者单位： 河北工业大学

项目金额： 25万元

中文摘要： 本项目拟通过阳极氧化法在医用钛合金表面构建纳米结构，然后采用物理和化学方法将钙、磷、羟基和胶原等生物友好离子和基团装载到纳米结构中，使钛合金表面具有良好的生物活性和生物相容性，并将抗菌剂银静电吸附到材料表面提高其抗菌性。通过模拟体液浸泡实验、细胞培养实验、细菌培养实验和动物实验对表面改性前后钛合金的生物学性能和抗菌性进行系统评价，研究阳极氧化法在钛合金表面加工纳米结构的机理和控制工艺；探索材料表面的纳米结构、功能基团与细菌、细胞及组织间的相互作用过程与机制；考察载银过程对表面结构、组成和生物学性能的影响；并对银离子的装载和释放过程建立相关模型。采用阳极氧化法在钛合金表面构建纳米结构，并装载生物友好的功能基团和抗菌剂以提高其生物学性能和抗菌性能是一项全新的课题，具有创新性，可为制备新型抗菌植入体材料提供科学依据，亦有望形成自主的知识产权。

中文关键词： 钛；阳极氧化；纳米结构；生物学性能；抗菌性

英文摘要： The nano-structures will be produced on titanium alloys by anodic oxidation. Some functional groups such as Ca, P, -OH and collagen will be physically or chemically assembled on the nano-surface to obtain good bioactivity and biocompatibility. Silver is also assembled on the modified titanium surface by electrostatic absorption to obtain antibacterial property. The biological and antibacterial properties of the titanium alloys before and after surface modification will be examined by simulated body fluid (SBF) soaking test, cell culture test, bacterial counting method and animal test. During the experiments, the mechanism of surface modification by anodic oxidation will be detected, so that the formation of nano-structures on titanium alloys can be controlled. The interaction among nano-structures and functional groups, bacterias, cells and tissues will be analyzed. Considering the influence of silver on surface structure, composition and biological properties, the models for silver loading and releasing processes will also be created. It is an original project to assemble functional groups and antibacterial on anodic oxidation modified titanium alloys, which may provide the prospect of forming new types of medical implants with good biological and antibacterial properties.

英文关键词： titanium；anodic oxidation；nano-structure；biological property；antibacterial property